Technology Process of 2-Propenoic acid, 1-ethenyl-4-[2-oxo-5-(phenylthio)-1-pyrrolidinyl]butyl
ester
There total 5 articles about 2-Propenoic acid, 1-ethenyl-4-[2-oxo-5-(phenylthio)-1-pyrrolidinyl]butyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at -78 ℃;
DOI:10.1055/s-2004-837197
- Guidance literature:
-
Multi-step reaction with 6 steps
1: imidazole / dimethylformamide
2: 68 percent / NH4F / methanol / 15 h / Heating
3: 90 percent / DIAD; PPh3 / tetrahydrofuran
4: 87 percent / LiBEt3H / tetrahydrofuran / -78 °C
5: 91 percent / APTS
6: 93 percent / Huenig's base / CH2Cl2 / -78 °C
With
1H-imidazole; ammonium fluoride; di-isopropyl azodicarboxylate; lithium triethylborohydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 8-aminopyrene-1,3,6-trisulfonic acid, trisodium salt;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-2004-837197
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 68 percent / NH4F / methanol / 15 h / Heating
2: 90 percent / DIAD; PPh3 / tetrahydrofuran
3: 87 percent / LiBEt3H / tetrahydrofuran / -78 °C
4: 91 percent / APTS
5: 93 percent / Huenig's base / CH2Cl2 / -78 °C
With
ammonium fluoride; di-isopropyl azodicarboxylate; lithium triethylborohydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 8-aminopyrene-1,3,6-trisulfonic acid, trisodium salt;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1055/s-2004-837197
