Furo[3,2-c]pyridine-3,4-dicarboxylic acid, 2,3-dihydro-, 4-(phenylmethyl) ester

Base Information

Chemical Name:Furo[3,2-c]pyridine-3,4-dicarboxylic acid, 2,3-dihydro-, 4-(phenylmethyl) ester
CAS No.:849437-78-1
Molecular Formula:C16H13NO5
Molecular Weight:299.283
Hs Code.:

Synonyms:

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Chemical Property of Furo[3,2-c]pyridine-3,4-dicarboxylic acid, 2,3-dihydro-, 4-(phenylmethyl) ester

Chemical Property:

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Technology Process of Furo[3,2-c]pyridine-3,4-dicarboxylic acid, 2,3-dihydro-, 4-(phenylmethyl) ester

There total 6 articles about Furo[3,2-c]pyridine-3,4-dicarboxylic acid, 2,3-dihydro-, 4-(phenylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 849437-77-0
benzyl (+/-)-2,3-dihydro-3-hydroxymethylfuro[3,2-c]pyridine-4-carboxylate

: 849437-78-1
(+/-)-4-benzyloxycarbonyl-2,3-dihydrofuro[3,2-c]pyridine-3-carboxylic acid

Guidance literature:: With ruthenium trichloride; sodium periodate; In tetrachloromethane; water; acetonitrile; at 20 ℃; for 3h;
DOI:10.3987/com-04-s(p)22

Reference yield:

: 206193-58-0
4-allyloxy-3-iodopicolinanilide

: 849437-78-1
(+/-)-4-benzyloxycarbonyl-2,3-dihydrofuro[3,2-c]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / sodium hydride / tetrahydrofuran / 2 h / 0 - 20 °C

2: 90 percent / lithium hydroxide / tetrahydrofuran; H₂O / 40 h / 20 °C

3: 91 percent / DCC; DMAP / CH₂Cl₂ / 20 h / 20 °C

4: 50 percent / tri-n-butyltin hydride; AIBN / toluene / 3 h / 80 °C

5: 32 percent / sodium-periodate; ruthenium chloride / acetonitrile; CCl₄; H₂O / 3 h / 20 °C

With dmap; ruthenium trichloride; lithium hydroxide; sodium periodate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; toluene; acetonitrile; 5: Sharpless-oxidation;
DOI:10.3987/com-04-s(p)22

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 849437-78-1
(+/-)-4-benzyloxycarbonyl-2,3-dihydrofuro[3,2-c]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / DCC; DMAP / CH₂Cl₂ / 20 h / 20 °C

2: 50 percent / tri-n-butyltin hydride; AIBN / toluene / 3 h / 80 °C

3: 32 percent / sodium-periodate; ruthenium chloride / acetonitrile; CCl₄; H₂O / 3 h / 20 °C

With dmap; ruthenium trichloride; sodium periodate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; dicyclohexyl-carbodiimide; In tetrachloromethane; dichloromethane; water; toluene; acetonitrile; 3: Sharpless-oxidation;
DOI:10.3987/com-04-s(p)22