Imidazo[1,2-a]pyridine-2-acetic acid, 8-amino-5,6,7,8-tetrahydro-6,7-bis(phenylmethoxy)-5-[(phenylmethoxy) methyl]-, methyl ester, (5R,6R,7R,8S)-

Base Information

Chemical Name:Imidazo[1,2-a]pyridine-2-acetic acid, 8-amino-5,6,7,8-tetrahydro-6,7-bis(phenylmethoxy)-5-[(phenylmethoxy) methyl]-, methyl ester, (5R,6R,7R,8S)-
CAS No.:849467-69-2
Molecular Formula:C32H35N3O5
Molecular Weight:541.647
Hs Code.:

Imidazo[1,2-a]pyridine-2-acetic acid,
8-amino-5,6,7,8-tetrahydro-6,7-bis(phenylmethoxy)-5-[(phenylmethoxy)
methyl]-, methyl ester, (5R,6R,7R,8S)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Imidazo[1,2-a]pyridine-2-acetic acid, 8-amino-5,6,7,8-tetrahydro-6,7-bis(phenylmethoxy)-5-[(phenylmethoxy) methyl]-, methyl ester, (5R,6R,7R,8S)-

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Technology Process of Imidazo[1,2-a]pyridine-2-acetic acid, 8-amino-5,6,7,8-tetrahydro-6,7-bis(phenylmethoxy)-5-[(phenylmethoxy) methyl]-, methyl ester, (5R,6R,7R,8S)-

There total 7 articles about Imidazo[1,2-a]pyridine-2-acetic acid, 8-amino-5,6,7,8-tetrahydro-6,7-bis(phenylmethoxy)-5-[(phenylmethoxy) methyl]-, methyl ester, (5R,6R,7R,8S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 849467-68-1
methyl (5R,6R,7S,8S)-8-azido-6,7-bis(benzyloxy)-5-[(benzyloxy)methyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-acetate

: 849467-69-2
methyl (5R,6R,7S,8S)-8-amino-6,7-bis(benzyloxy)-5-[(benzyloxy)methyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-acetate

Guidance literature:: With 1.3-propanedithiol; triethylamine; In methanol; at 23 ℃; for 23h;
DOI:10.1002/hlca.200490286

Reference yield:

: 847372-42-3
methyl 3-amino-4,4-dimethoxybutanoate

: 849467-69-2
methyl (5R,6R,7S,8S)-8-amino-6,7-bis(benzyloxy)-5-[(benzyloxy)methyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: HgCl₂ / tetrahydrofuran / 19 h / 23 °C

1.2: TsOH*H₂O / toluene / 40 h / 60 °C

2.1: 6 percent / DPPA; DBU / toluene / 22 h / 23 °C

3.1: 85 percent / Et₃N; HS-(CH₂)3-SH / methanol / 23 h / 23 °C

With 1.3-propanedithiol; diphenyl-phosphinic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; mercury dichloride; In tetrahydrofuran; methanol; toluene;
DOI:10.1002/hlca.200490286

Reference yield:

: 272124-00-2
2-O-acetyl-5-amino-3,4,6-tri-O-benzyl-5-deoxy-D-gluconothiolactam

: 849467-69-2
methyl (5R,6R,7S,8S)-8-amino-6,7-bis(benzyloxy)-5-[(benzyloxy)methyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: HgCl₂ / tetrahydrofuran / 19 h / 23 °C

1.2: TsOH*H₂O / toluene / 40 h / 60 °C

2.1: 6 percent / DPPA; DBU / toluene / 22 h / 23 °C

3.1: 85 percent / Et₃N; HS-(CH₂)3-SH / methanol / 23 h / 23 °C

With 1.3-propanedithiol; diphenyl-phosphinic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; mercury dichloride; In tetrahydrofuran; methanol; toluene;
DOI:10.1002/hlca.200490286