Cyclohexanecarboxylic acid, 1-cyano-3-methylene-2-[(2E)-3-phenyl-2-propenylidene]-, 1-methylethyl ester, (2E)-

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Chemical Name:Cyclohexanecarboxylic acid, 1-cyano-3-methylene-2-[(2E)-3-phenyl-2-propenylidene]-, 1-methylethyl ester, (2E)-
CAS No.:849517-73-3
Molecular Formula:C21H23NO2
Molecular Weight:321.419
Hs Code.:

Synonyms:

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Chemical Property of Cyclohexanecarboxylic acid, 1-cyano-3-methylene-2-[(2E)-3-phenyl-2-propenylidene]-, 1-methylethyl ester, (2E)-

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Technology Process of Cyclohexanecarboxylic acid, 1-cyano-3-methylene-2-[(2E)-3-phenyl-2-propenylidene]-, 1-methylethyl ester, (2E)-

There total 3 articles about Cyclohexanecarboxylic acid, 1-cyano-3-methylene-2-[(2E)-3-phenyl-2-propenylidene]-, 1-methylethyl ester, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 103-64-0,1340-14-3
bromostyrene

: 849517-58-4
2-cyano-6-methyleneoct-7-ynoic acid isopropyl ester

: 849517-73-3
(E)-1-cyano-3-methylene-2-(3-phenylprop-2-enylidene)cyclohexanecarboxylic acid isopropyl ester

Guidance literature:: bromostyrene; 2-cyano-6-methyleneoct-7-ynoic acid isopropyl ester; With 18-crown-6 ether; potassium hydride; In tetrahydrofuran; at 20 ℃; for 0.25h;

With n-butyllithium; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; hexane; at 30 ℃; for 5h;
DOI:10.1055/s-2004-834879

Reference yield:

: 110316-91-1
4-methylenehex-5-yn-1-ol

: 849517-73-3
(E)-1-cyano-3-methylene-2-(3-phenylprop-2-enylidene)cyclohexanecarboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 89 percent / imidazole; I₂; PPh₃ / acetonitrile; diethyl ether

2.1: NaH / tetrahydrofuran / 0 °C

2.2: 53 percent / tetrahydrofuran; dimethylformamide / 2 h / 20 °C

3.1: KH; 18-crown-6 / tetrahydrofuran / 0.25 h / 20 °C

3.2: 70 percent / n-BuLi / PdCl₂(PPh₃)2 / tetrahydrofuran; hexane / 5 h / 30 °C

With 1H-imidazole; 18-crown-6 ether; iodine; potassium hydride; sodium hydride; triphenylphosphine; In tetrahydrofuran; diethyl ether; acetonitrile;
DOI:10.1055/s-2004-834879

Reference yield:

: 849517-53-9
6-iodo-3-methylene-hex-1-yne

: 849517-73-3
(E)-1-cyano-3-methylene-2-(3-phenylprop-2-enylidene)cyclohexanecarboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 0 °C

1.2: 53 percent / tetrahydrofuran; dimethylformamide / 2 h / 20 °C

2.1: KH; 18-crown-6 / tetrahydrofuran / 0.25 h / 20 °C

2.2: 70 percent / n-BuLi / PdCl₂(PPh₃)2 / tetrahydrofuran; hexane / 5 h / 30 °C

With 18-crown-6 ether; potassium hydride; sodium hydride; In tetrahydrofuran;
DOI:10.1055/s-2004-834879