α-BroMo-N-benzyl-N-MethylacetaMide

Base Information

• Chemical Name: α-BroMo-N-benzyl-N-MethylacetaMide
• CAS No.: 73391-96-5
• Molecular Formula: C10H12BrNO
• Molecular Weight: 242.115
• Mol file: 73391-96-5.mol

Synonyms:N-benzyl-2-bromo-N-methylethanamide;

Chemical Property of α-BroMo-N-benzyl-N-MethylacetaMide

Chemical Property:

• Vapor Pressure: 0.000217mmHg at 25°C
• Boiling Point: 326.4°Cat760mmHg
• PKA: -1.07±0.70(Predicted)
• Flash Point: 151.2°C
• PSA: 20.31000
• Density: 1.4g/cm³
• LogP: 2.03990

Purity/Quality:

99%, ^*data from raw suppliers

α-Bromo-N-benzyl-N-methylacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An α-bromo amides that inactivates α-chymotrypsin.

Technology Process of α-BroMo-N-benzyl-N-MethylacetaMide

There total 1 articles about α-BroMo-N-benzyl-N-MethylacetaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-Bromoacetyl bromide (598-21-0) + benzyl-methyl-amine (103-67-3) → N-methyl-N-(phenylmethyl)-2-bromoacetamide (73391-96-5)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1021/jm200770f

Reference yield: 98.0%

N-methyl-N-(phenylmethyl)-2-bromoacetamide (73391-96-5) + triethyl phosphite (122-52-1) → [(benzyl-methyl-carbamoyl)-methyl]-phosphonic acid diethyl ester (883231-60-5)

Guidance literature:

With sodium iodide; In N,N-dimethyl-formamide; for 0.025h; Microwave irradiation;

DOI:10.1080/00397911.2010.530377

Reference yield: 86.0%

5,10-dihydro-11H-dibenzo[b,e][1,4]-diazepin-11-one (5814-41-5) + N-methyl-N-(phenylmethyl)-2-bromoacetamide (73391-96-5) → N-benzyl-N-methyl-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)acetamide

Guidance literature:

5,10-dihydro-11H-dibenzo[b,e][1,4]-diazepin-11-one; With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

N-methyl-N-(phenylmethyl)-2-bromoacetamide; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2020.112725

upstream raw materials:

2-Bromoacetyl bromide

benzyl-methyl-amine

Downstream raw materials:

10-(N-benzyl-N-methylcarbamoylmethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid

1-(N-benzyl-N-methylcarbamoylmethyl)-4,7,10-tris(ethoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane

N-benzyl-N-methyl-2-(4-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazolo[3,4-b]quinolin-1-yl)acetamide

[(benzyl-methyl-carbamoyl)-methyl]-phosphonic acid diethyl ester