3,4-Diphenylisoxazole

Base Information

• Chemical Name: 3,4-Diphenylisoxazole
• CAS No.: 7467-78-9
• Molecular Formula: C15H11NO
• Molecular Weight: 221.258
• Hs Code.: 2934999090
• Mol file: 7467-78-9.mol

Synonyms:4,5-diphenylisoxazole;3,4-Diphenyl-isoxazol (XXII);Isoxazole,3,4-diphenyl;Isoxazole,4-diphenyl;3,4-Diphenyl-isoxazol;3,4-diphenylisoxazole;

Chemical Property of 3,4-Diphenylisoxazole

Chemical Property:

• Vapor Pressure: 7.4E-05mmHg at 25°C
• Boiling Point: 353.2°Cat760mmHg
• Flash Point: 126.8°C
• PSA: 26.03000
• Density: 1.128g/cm³
• LogP: 4.00860

Purity/Quality:

99% ^*data from raw suppliers

3,4-DIPHENYL ISOXAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,4-Diphenylisoxazole

There total 36 articles about 3,4-Diphenylisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl (1S*,5R*)-4,5-diphenyl-2-oxa-3,7-diazabicyclo[3.2.0]hept-3-ene-7-carboxylate → 3,4-diphenyl-isoxazole (7467-78-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b02848

Reference yield: 86.0%

trans-3,4-diphenyl-5-nitro-Δ2-isoxazoline (50899-23-5,115335-20-1) → 3,4-diphenyl-isoxazole (7467-78-9)

Guidance literature:

In toluene; Heating;

Reference yield: 67.0%

(4S,5R)-5-Methylsulfanyl-3,4-diphenyl-4,5-dihydro-isoxazole (85978-01-4,85978-04-7) → 3,4-diphenyl-isoxazole (7467-78-9)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; Ambient temperature;

DOI:10.1016/S0040-4020(01)91846-0

upstream raw materials:

(4-chloro-phenyl)-(3,4-diphenyl-isoxazol-5-yl)-ketone

2,4-diphenyl-1,3-oxazole

3,4t-diphenyl-4,5-dihydro-isoxazol-5r-ol

phenylacetylene

Downstream raw materials:

2-phenyl-2-(trimethylsilyl)ethenone

(E)-benzil monooxime

(Z)-benzilmonooxime

Refernces

• 1、 Cheng, Jiaxin,Yang, Ze,Li, Yuansheng,Xi, Yulan,Sun, Qiu,He, Ling. "Synthesis of Isoxazolines and Isoxazoles via Metal-Free Desulfitative Cyclization". . p. 2385 - 2393. Retrieved 2018/05/28.
• 2、 Brahma, Sulagna,Ray, Jayanta K.. "Synthesis of azirines containing aldehyde functionality and their utilization as synthetic tools for five membered oxazoles and isoxazoles". . p. 311 - 317. Retrieved 2008/09/20.