Ladarixin

Base Information

Chemical Name:Ladarixin
CAS No.:849776-05-2
Molecular Formula:C11H12F3NO6S2
Molecular Weight:375.347
Hs Code.:
UNII:DEH7Q6472O
ChEMBL ID:CHEMBL189475
DSSTox Substance ID:DTXSID50234030
NCI Thesaurus Code:C170087
Pharos Ligand ID:ADYHMNDM4ZZF
Wikidata:Q27276351

Synonyms:2'-((4'-trifluoromethanesulfonyloxy)phenyl)-N-methanesulfonylpropionamide;DF 2156A;DF 2156Y;DF-2156A;DF-2156Y;DF2156A;DF2156Y;ladarixin

Suppliers and Price of Ladarixin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Ladarixin

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:5
Exact Mass:375.00581394
Heavy Atom Count:23
Complexity:624

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=CC=C(C=C1)OS(=O)(=O)C(F)(F)F)C(=O)NS(=O)(=O)C
Isomeric SMILES:C[C@H](C1=CC=C(C=C1)OS(=O)(=O)C(F)(F)F)C(=O)NS(=O)(=O)C
Recent ClinicalTrials:A Single Dose Study About the Influence of Food on the Oral Bioavailability of Ladarixin Capsule in Healthy Volunteers
Recent EU Clinical Trials:A phase 2, multicentre, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of 400 mg twice a day oral ladarixin in patients with new-onset type 1 diabetes

Technology Process of Ladarixin

There total 5 articles about Ladarixin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 3144-09-0
methanesulfonamide

: 849776-05-2
Meraxin

Guidance literature:: (R)-(-)-2-(4-trifluoromethanesulfonyloxy)phenylpropionic acid; In dichloromethane; at 20 ℃; for 1.5h;

methanesulfonamide; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃;

Reference yield: 79.0%

: 533931-60-1
(R)-(-)-2-(4-trifluoromethanesulfonyloxy)phenylpropionic acid

: 3144-09-0
methanesulfonamide

: 849776-05-2
Meraxin

Guidance literature:: (R)-(-)-2-(4-trifluoromethanesulfonyloxy)phenylpropionic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 1.5h;

methanesulfonamide; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/jm049227l

Reference yield:

: 533931-57-6
(R)-2-(4-hydroxyphenyl)propionic acid methyl ester

: 849776-05-2
Meraxin

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / N,N-diisopropylamine / CH₂Cl₂ / 3 h / 20 °C

2.1: 83 percent / aq. HCl; glacial acetic acid / 3 h / Heating

3.1: 1,1'-carbonyldiimidazole / CH₂Cl₂ / 1.5 h / 20 °C

3.2: 79 percent / DBU / CH₂Cl₂ / 16 h / 20 °C

With hydrogenchloride; acetic acid; diisopropylamine; 1,1'-carbonyldiimidazole; In dichloromethane;
DOI:10.1021/jm049227l