Benzoic acid, 2-aMino-4-[[(1,1-diMethylethoxy)carbonyl]aMino]-, Methyl ester

Base Information

• Chemical Name: Benzoic acid, 2-aMino-4-[[(1,1-diMethylethoxy)carbonyl]aMino]-, Methyl ester
• CAS No.: 849792-91-2
• Molecular Formula: C13H18N2O4
• Molecular Weight: 266.297
• Hs Code.: 2924299090
• Mol file: 849792-91-2.mol

Synonyms:

Chemical Property of Benzoic acid, 2-aMino-4-[[(1,1-diMethylethoxy)carbonyl]aMino]-, Methyl ester

Chemical Property:

• PSA: 94.14000
• LogP: 2.99720
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-amino-4-((tert-butoxycarbonyl)amino)benzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 2-aMino-4-[[(1,1-diMethylethoxy)carbonyl]aMino]-, Methyl ester

There total 1 articles about Benzoic acid, 2-aMino-4-[[(1,1-diMethylethoxy)carbonyl]aMino]-, Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-tert-butoxycarbonylamino-2-nitro-benzoic acid methyl ester (849793-86-8) → 2-amino-4-(tert-butoxycarbonylamino)-benzoic acid methyl ester (849792-91-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethyl acetate; for 24 - 36h;

Reference yield: 44.0%

2-amino-4-(tert-butoxycarbonylamino)-benzoic acid methyl ester (849792-91-2) + 4-Nitrophenyl isocyanate (100-28-7) → tert-butyl 3-(4-aminophenyl)-1,2,3,4-tetrahydro-2,4-dioxoquinazolin-7-ylcarbamate (849792-92-3)

Guidance literature:

2-amino-4-(tert-butoxycarbonylamino)-benzoic acid methyl ester; 4-Nitrophenyl isocyanate; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

With diisopropylamine; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

With hydrogen; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide; for 20h;

Reference yield:

2-amino-4-(tert-butoxycarbonylamino)-benzoic acid methyl ester (849792-91-2) → 5-chloro-N-[(4-(7-amino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenylamino)carbonyl]thiophene-2-sulfonamide (849792-93-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide / 20 h / 20 °C

1.2: 2 h / 80 °C

1.3: 20 h

2.1: toluene / 16 h / Heating / reflux

2.2: 1 h

In N,N-dimethyl-formamide; toluene;

upstream raw materials:

4-tert-butoxycarbonylamino-2-nitro-benzoic acid methyl ester

Downstream raw materials:

tert-butyl 3-(4-aminophenyl)-1,2,3,4-tetrahydro-2,4-dioxoquinazolin-7-ylcarbamate

5-chloro-N-[(4-(7-amino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenylamino)carbonyl]thiophene-2-sulfonamide

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