4-Hydroxy-2-methoxy-6-methylbenzoic acid

Base Information

• Chemical Name: 4-Hydroxy-2-methoxy-6-methylbenzoic acid
• CAS No.: 3733-95-7
• Molecular Formula: C9H10O4
• Molecular Weight: 182.176
• Hs Code.: 2918990090
• European Community (EC) Number: 833-053-0
• Nikkaji Number: J2.370.651B
• Mol file: 3733-95-7.mol

Synonyms:4-hydroxy-2-methoxy-6-methylbenzoic acid;Isoevernic acid;3733-95-7;SCHEMBL10823716;CHEBI:144261;2-methoxy-4-hydroxy-6-methylbenzoic acid;EN300-2615350

Chemical Property of 4-Hydroxy-2-methoxy-6-methylbenzoic acid

Chemical Property:

• PSA: 66.76000
• LogP: 1.40740
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 182.05790880
• Heavy Atom Count: 13
• Complexity: 192

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CC(=C1C(=O)O)OC)O

Technology Process of 4-Hydroxy-2-methoxy-6-methylbenzoic acid

There total 9 articles about 4-Hydroxy-2-methoxy-6-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

umbilicaric acid (30666-92-3) → orcinol (504-15-4) + 4-hydroxy-2-methoxy-6-methylbenzoic acid (3733-95-7) + methylammonium carbonate (15719-64-9,15719-76-3,97762-63-5)

Guidance literature:

laengeres Kochen;

DOI:10.1007/BF02975094 DOI:10.1007/BF02665867

Reference yield:

2-formyl-4-((4-((4-((4-((3-formyl-2,4-dihydroxy-6-methylbenzoyl)oxy)-2-methoxy-6-methylbenzoyl)oxy)-2-methoxy-6-methylbenzoyl)oxy)-2-methoxy-6-methylbenzoyl)oxy)-3-methoxy-5-methylbenzoic acid → acide formyl-3-dihydroxy-2,4-methyl-6-benzoique (479-25-4) + 4-hydroxy-2-methoxy-6-methylbenzoic acid (3733-95-7) + 2-formyl-4-hydroxy-3-methoxy-5-methylbenzoic acid

Guidance literature:

With potassium hydroxide; In methanol; water; Reflux;

DOI:10.14233/ajchem.2019.21734

Reference yield:

2-methoxy-4-methoxycarbonyloxy-6-methyl-benzoic acid (866997-06-0) → 4-hydroxy-2-methoxy-6-methylbenzoic acid (3733-95-7)

Guidance literature:

With sodium hydroxide; at 20 ℃;

upstream raw materials:

1-methyl-4-nitrosobenzene

umbilicaric acid

4-Hydroxy-2-methoxy-6-methylbenzoesaeure-methylester

2-methoxy-4-methoxycarbonyloxy-6-methyl-benzoic acid