3-(4-METHYL-PIPERAZIN-1-YL)-PROPIONIC ACID ETHYL ESTER >98%

Base Information

• Chemical Name: 3-(4-METHYL-PIPERAZIN-1-YL)-PROPIONIC ACID ETHYL ESTER >98%
• CAS No.: 7148-05-2
• Molecular Formula: C10H20N2O2
• Molecular Weight: 200.281
• Hs Code.: 29335990
• Mol file: 7148-05-2.mol

Synonyms:Ethyl 3-(4-methylpiperazin-1-yl)propanoate;3-(4-Methyl-piperazin-1-yl)-propionic acid ethyl ester;

Chemical Property of 3-(4-METHYL-PIPERAZIN-1-YL)-PROPIONIC ACID ETHYL ESTER >98%

Chemical Property:

• Vapor Pressure: 0.00581mmHg at 25°C
• Refractive Index: 1.467
• Boiling Point: 273.2 °C at 760 mmHg
• Flash Point: 119 °C
• PSA: 32.78000
• Density: 1.005 g/cm³
• LogP: 0.06280

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 3-(4-methylpiperazin-1-yl)propanoate 98.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-METHYL-PIPERAZIN-1-YL)-PROPIONIC ACID ETHYL ESTER >98%

There total 3 articles about 3-(4-METHYL-PIPERAZIN-1-YL)-PROPIONIC ACID ETHYL ESTER >98% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-methyl-piperazine (109-01-3) + ethyl acrylate (140-88-5,9003-32-1) → ethyl 3-(4-methylpiperazin-1-yl)propanoate (7148-05-2)

Guidance literature:

With CLEA Pseudomonas stutzeri lipase (PSL); In hexane; at 60 ℃; for 96h; Sealed tube; Enzymatic reaction;

DOI:10.1021/jo400268u

Reference yield:

1-methyl-piperazine (109-01-3) + ethyl 3-chloropropanoate (623-71-2) → ethyl 3-(4-methylpiperazin-1-yl)propanoate (7148-05-2)

Guidance literature:

DOI:10.1016/j.ejmech.2011.03.003

Reference yield:

→ ethyl 3-(4-methylpiperazin-1-yl)propanoate (7148-05-2)

Guidance literature:

N-Methylpiperazin, Acrylsaeureethylester;

upstream raw materials:

1-methyl-piperazine

ethyl acrylate

ethyl 3-chloropropanoate

Downstream raw materials:

3-(4-methylpiperazin-1-yl)-N'-{2-[(2-nitrophenyl)thio]phenyl}propanehydrazide

N'-{2-[(4-chloro-2-nitrophenyl)thio]phenyl}-3-(4-methylpiperazin-1-yl)propanehydrazide

N'-{2-[(4-methoxy-2-nitrophenyl)thio]phenyl}-3-(4-methylpiperazin-1-yl)propanehydrazide

N'-{2-[(2,4-dinitrophenyl)thio]phenyl}-3-(4-methylpiperazin-1-yl)propanehydrazide

Refernces

• 1、 Steunenberg, Peter,Sijm, Maarten,Zuilhof, Han,Sanders, Johan P. M.,Scott, Elinor L.,Franssen, Maurice C. R.. "Lipase-catalyzed aza-michael reaction on acrylate derivatives". . p. 3802 - 3813. Retrieved 2013/06/05.
• 2、 Yadav,Ramesh Reddy,Gopal Rao,Narsaiah,Subba Reddy. "Samarium(III) triflate catalyzed conjugate addition of amines to electron-deficient alkenes". . p. 3447 - 3450. Retrieved 2008/09/19.