5-Amino-2-isopropylphenol

Base Information

• Chemical Name: 5-Amino-2-isopropylphenol
• CAS No.: 850085-99-3
• Molecular Formula: C9H13NO
• Molecular Weight: 151.208
• Mol file: 850085-99-3.mol

Synonyms:5-amino-2-i-propylphenol;5-Amino-2-isopropyl-phenol;

Chemical Property of 5-Amino-2-isopropylphenol

Chemical Property:

• PSA: 46.25000
• LogP: 2.67900

Purity/Quality:

99% ^*data from raw suppliers

5-Amino-2-isopropylphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Amino-2-isopropylphenol

There total 4 articles about 5-Amino-2-isopropylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-nitro-2-i-propylphenol (170230-13-4) → 5-amino-2-isopropylphenol (850085-99-3)

Guidance literature:

With hydrogen; platinum(IV) oxide; under 760 Torr;

DOI:10.1016/j.bmcl.2005.10.037

Reference yield:

2-isopropyl-5-nitroaniline (132475-93-5) → 5-amino-2-isopropylphenol (850085-99-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaNO₂

1.2: H₂O / 80 °C

2.1: H₂ / PtO₂ / 760 Torr

With hydrogen; sodium nitrite; platinum(IV) oxide;

DOI:10.1016/j.bmcl.2005.10.037

Reference yield:

2-isopropylaniline (643-28-7) → 5-amino-2-isopropylphenol (850085-99-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: KNO₃; H₂SO₄

2.1: NaNO₂

2.2: H₂O / 80 °C

3.1: H₂ / PtO₂ / 760 Torr

With sulfuric acid; hydrogen; potassium nitrate; sodium nitrite; platinum(IV) oxide;

DOI:10.1016/j.bmcl.2005.10.037

upstream raw materials:

5-nitro-2-i-propylphenol

2-isopropyl-5-nitroaniline

2-isopropylaniline

Downstream raw materials:

2-i-propyl-5-(thiazol-2-ylamino)phenol

Refernces

• 1、 Ruiz-Caro, Juliana,Basavapathruni, Aravind,Kim, Joseph T.,Bailey, Christopher M.,Wang, Ligong,Anderson, Karen S.,Hamilton, Andrew D.,Jorgensen, William L.. "Optimization of diarylamines as non-nucleoside inhibitors of HIV-1 reverse transcriptase". . p. 668 - 671. Retrieved 2007/10/03.