Chemical Property of Ccris 4434
Chemical Property:
- Vapor Pressure:7.57E-35mmHg at 25°C
- Melting Point:<3200(dec)
- Refractive Index:1.6630 (estimate)
- Boiling Point:864.4 °C at 760 mmHg
- PKA:3?+-.0.23(Predicted)
- Flash Point:476.6 °C
- PSA：268.28000
- Density:1.222 g/cm3
- LogP:4.29370
- Storage Temp.:−20°C
- Solubility.:DMSO (Slightly), Methanol (Slightly)
- XLogP3:1.2
- Hydrogen Bond Donor Count:7
- Hydrogen Bond Acceptor Count:15
- Rotatable Bond Count:31
- Exact Mass:705.39355556
- Heavy Atom Count:49
- Complexity:1040
- Purity/Quality:
-
98%,99%, *data from raw suppliers
Fumonisin B2 *data from reagent suppliers
Safty Information:
- Pictogram(s):
T+
- Hazard Codes:T+,T,Xn,F
- Statements:
26/27/28-36/37/38-40-36-20/21/22-11
- Safety Statements:
22-36/37/39-45-36/37-16-26
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CCCCC(C)C(C(CC(C)CCCCCCC(CC(C(C)N)O)O)OC(=O)CC(CC(=O)O)C(=O)O)OC(=O)CC(CC(=O)O)C(=O)O
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Description
Fumonisin B2 belongs to the family of toxins known as fumonisins. It is produced by several species of Fusarium molds primarily by Fusarium verticillioide. It is one of the major mycotoxin contaminant in corn and corn-based foods. Fumonisin B2 is a structural analog of fumonisin B1 but it is more cytotoxic than the latter and it inhibits sphinganine-N-acetyltransferase (ceramide synthase).Fumonisin B2 is a carcinogenic mycotoxin generally present on corn based food and feed-stuff, which is produced by the fungus Fusarium verticillioides and Fusarium moniliforme. Fumonisin B2 can also be detected in the industrially important fungi, Aspergillus niger.
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Uses
A mycotoxin produced by mold associated with corn. Inhibitor of sphingosine N-acyltransferase. Blocks the formation of ceramide from sphingosine. Fumonisin B2 is a minor analogue of a family of potent mycotoxins produced by various Fusarium species, associated with animal toxicity worldwide. To date much of the research on the pharmacology of the fumonisins has focused on fumonisin B1. It is generally accepted that fumonisin B2 acts on ceramide biosynthesis, however, the pharmacology of the minor analogues is less well explored. Contact herbicide used also to produce desiccation and defoliation
