Carbamic acid, [[4-chloro-2-[[[[(2S)-1-[(5-hydroxy-5H-indeno[1,2-c]pyridin-5-yl)carbonyl] -2-pyrrolidinyl]carbonyl]amino]methyl]phenyl]methyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [[4-chloro-2-[[[[(2S)-1-[(5-hydroxy-5H-indeno[1,2-c]pyridin-5-yl)carbonyl] -2-pyrrolidinyl]carbonyl]amino]methyl]phenyl]methyl]-, 1,1-dimethylethyl ester
CAS No.:850162-90-2
Molecular Formula:C31H33ClN4O5
Molecular Weight:577.08
Hs Code.:

Carbamic acid,
[[4-chloro-2-[[[[(2S)-1-[(5-hydroxy-5H-indeno[1,2-c]pyridin-5-yl)carbonyl]
-2-pyrrolidinyl]carbonyl]amino]methyl]phenyl]methyl]-, 1,1-dimethylethyl
ester

Synonyms:

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Chemical Property of Carbamic acid, [[4-chloro-2-[[[[(2S)-1-[(5-hydroxy-5H-indeno[1,2-c]pyridin-5-yl)carbonyl] -2-pyrrolidinyl]carbonyl]amino]methyl]phenyl]methyl]-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [[4-chloro-2-[[[[(2S)-1-[(5-hydroxy-5H-indeno[1,2-c]pyridin-5-yl)carbonyl] -2-pyrrolidinyl]carbonyl]amino]methyl]phenyl]methyl]-, 1,1-dimethylethyl ester

There total 11 articles about Carbamic acid, [[4-chloro-2-[[[[(2S)-1-[(5-hydroxy-5H-indeno[1,2-c]pyridin-5-yl)carbonyl] -2-pyrrolidinyl]carbonyl]amino]methyl]phenyl]methyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 850162-89-9
3-aza-9-hydroxy-9-fluorene carboxylic acid hydrazide

: 439117-44-9
(S)-tert-butyl 4-chloro-2-((pyrrolidine-2-carboxamido)methyl)benzylcarbamate

: 850162-90-2
3-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide

Guidance literature:: 3-aza-9-hydroxy-9-fluorene carboxylic acid hydrazide; With hydrogenchloride; n-Amyl nitrite; In tetrahydrofuran; N,N-dimethyl-formamide; at -20 ℃;

(S)-tert-butyl 4-chloro-2-((pyrrolidine-2-carboxamido)methyl)benzylcarbamate; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at -20 ℃; for 24h;
DOI:10.1021/jm049423s

Reference yield:

: 850162-88-8
3-aza-9-hydroxy-9-fluorene carboxylic acid methyl ester

: 850162-90-2
3-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 90 percent / hydrazine / 2 h / 20 °C

2.1: HCl(gas); amyl nitrite / dimethylformamide; tetrahydrofuran / -20 °C

2.2: 13 percent / N,N-diisopropylethylamine / tetrahydrofuran; dimethylformamide / 24 h / -20 °C

With hydrogenchloride; n-Amyl nitrite; hydrazine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm049423s

Reference yield:

: 9-trimethylsilanyloxy-9H-3-aza-fluorene-9-carbonitrile

: 850162-90-2
3-aza-9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2.2 g / HCl(gas) / 2 h / 20 °C

2.1: 90 percent / hydrazine / 2 h / 20 °C

3.1: HCl(gas); amyl nitrite / dimethylformamide; tetrahydrofuran / -20 °C

3.2: 13 percent / N,N-diisopropylethylamine / tetrahydrofuran; dimethylformamide / 24 h / -20 °C

With hydrogenchloride; n-Amyl nitrite; hydrazine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm049423s