6-Oxa-2-azabicyclo[3.1.0]hexane-3-carboxylic acid, 5-[(1,1-dimethylethyl)dimethylsilyl]-1-methyl-2-[(4-methylphenyl)sulfonyl]-, ethyl ester, (3S)-

Base Information

Chemical Name:6-Oxa-2-azabicyclo[3.1.0]hexane-3-carboxylic acid, 5-[(1,1-dimethylethyl)dimethylsilyl]-1-methyl-2-[(4-methylphenyl)sulfonyl]-, ethyl ester, (3S)-
CAS No.:850172-20-2
Molecular Formula:C21H33NO5SSi
Molecular Weight:439.648
Hs Code.:

6-Oxa-2-azabicyclo[3.1.0]hexane-3-carboxylic acid,
5-[(1,1-dimethylethyl)dimethylsilyl]-1-methyl-2-[(4-methylphenyl)sulfonyl]-,
ethyl ester, (3S)-

Synonyms:

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Chemical Property of 6-Oxa-2-azabicyclo[3.1.0]hexane-3-carboxylic acid, 5-[(1,1-dimethylethyl)dimethylsilyl]-1-methyl-2-[(4-methylphenyl)sulfonyl]-, ethyl ester, (3S)-

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Technology Process of 6-Oxa-2-azabicyclo[3.1.0]hexane-3-carboxylic acid, 5-[(1,1-dimethylethyl)dimethylsilyl]-1-methyl-2-[(4-methylphenyl)sulfonyl]-, ethyl ester, (3S)-

There total 3 articles about 6-Oxa-2-azabicyclo[3.1.0]hexane-3-carboxylic acid, 5-[(1,1-dimethylethyl)dimethylsilyl]-1-methyl-2-[(4-methylphenyl)sulfonyl]-, ethyl ester, (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 850172-14-4
ethyl 4-tert-butyldimethylsilyl-5-methyl-N-(p-toluenesulfonyl)-2-(4-pyrroline)carboxylate

: 850172-20-2
ethyl 4-tert-butyldimethylsilyl-5-methyl-N-(p-toluenesulfonyl)-2-(4,5-epoxypyrrolidine)carboxylate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1021/ol047343c

Reference yield:

: 83670-53-5
(E)-ethyl 2-(tosylimino)acetate

: 850172-20-2
ethyl 4-tert-butyldimethylsilyl-5-methyl-N-(p-toluenesulfonyl)-2-(4,5-epoxypyrrolidine)carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: [Cu(MeCN)4]PF₆; (R)-DM-SEGPHOS / benzene / 3 h / Heating

2: 90 percent / m-CPBA / CH₂Cl₂ / 3 h / 0 °C

With (R)-(+)-(4,4'-bi-1,3-benzodioxole)-5,5'-diylbis(di(3,5-dimethylphenyl)phosphine); tetrakis(actonitrile)copper(I) hexafluorophosphate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; benzene;
DOI:10.1021/ol047343c

Reference yield:

: 99035-24-2
1-Methyl-1-(tert-butyldimethylsilyl)allene

: 850172-20-2
ethyl 4-tert-butyldimethylsilyl-5-methyl-N-(p-toluenesulfonyl)-2-(4,5-epoxypyrrolidine)carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: [Cu(MeCN)4]PF₆; (R)-DM-SEGPHOS / benzene / 3 h / Heating

2: 90 percent / m-CPBA / CH₂Cl₂ / 3 h / 0 °C

With (R)-(+)-(4,4'-bi-1,3-benzodioxole)-5,5'-diylbis(di(3,5-dimethylphenyl)phosphine); tetrakis(actonitrile)copper(I) hexafluorophosphate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; benzene;
DOI:10.1021/ol047343c