Coreg CR

Base Information

• Chemical Name: Coreg CR
• CAS No.: 610309-89-2
• Molecular Formula: C₂₄H₂₆N₂O₄*0H₂O*H₃O₄P
• Molecular Weight: 513.484
• European Community (EC) Number: 642-914-8
• UNII: EQT531S367
• DSSTox Substance ID: DTXSID60976535
• Wikidata: Q27277316
• NCI Thesaurus Code: C65292
• RXCUI: 668310
• Mol file: 610309-89-2.mol

Synonyms:Carvedilol phosphate;Coreg CR;610309-89-2;Carvedilol phosphate hemihydrate;Carvedilol dihydrogen phosphate hemihydrate;Carvedilol phosphate [USAN];SKF 105517D;UNII-EQT531S367;EQT531S367;SK&F-105517-D;Carvedilol phosphate hydrate;1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol;phosphoric acid;hydrate;Carvedilol phosphate (USAN);Carvedilol phosphate hydrate (JAN);(2RS)-1-(9H-Carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol phosphate salt (1:1) hemihydrate;2-Propanol, 1-(9H-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-, phosphate (salt), hydrate (2:2:1);CARVEDILOL PHOSPHATE HYDRATE [JAN];SKF-105517D;BM 14190 (phosphate hemihydrate);(2RS)-1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]propan-2-ol phosphate salt (1:1) hemihydrate;Coreg CR (TN);Carvedilol Phosphate Salt;D03415;DTXSID60976535;LHNYXTULDSJZRB-UHFFFAOYSA-N;BCP28563;CARVEDILOL PHOSPHATE [VANDF];AKOS026749869;CARVEDILOL PHOSPHATE [ORANGE BOOK];F88523;CARVEDILOL PHOSPHATE HEMIHYDRATE [WHO-DD];Q27277316;2-PROPANOL, 1-(9H-CARBAZOL-4-YLOXY)-3-((2-(2-METHOXYPHENOXY)ETHYL)AMINO) , PHOSPHATE (SALT), HYDRATE (2:2:1)

Chemical Property of Coreg CR

Chemical Property:

• Vapor Pressure: 4.63E-18mmHg at 25°C
• Boiling Point: 655.2 °C at 760 mmHg
• Flash Point: 350.1 °C
• PSA: 172.54000
• LogP: 3.13600
• Hydrogen Bond Donor Count: 13
• Hydrogen Bond Acceptor Count: 19
• Rotatable Bond Count: 20
• Exact Mass: 1026.34287045
• Heavy Atom Count: 71
• Complexity: 557

Purity/Quality:

99% ^*data from raw suppliers

Carvedilolphosphatehemihydrate 98+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O.COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O.O.OP(=O)(O)O.OP(=O)(O)O
• Recent ClinicalTrials: Efficacy of Coreg CR and Lisinopril on Markers for Cardiovascular Functional and Structural Disease
• Uses: Treatment of congestive heart failure, left ventricular dysfunction following myocardial infarction, and management of hypertension.

Technology Process of Coreg CR

There total 13 articles about Coreg CR which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

carvedilol (72956-09-3) → carvedilol dihydrogen phosphate hemihydrate (610309-89-2)

Guidance literature:

With phosphorus pentoxide; In water; acetone; at 0 - 45 ℃; for 1h; Product distribution / selectivity;

Reference yield:

carvedilol phosphate hemihydrate (610309-89-2) → carvedilol dihydrogen phosphate dihydrate (610309-89-2)

Guidance literature:

With water; In acetone; at 10 - 30 ℃;

Reference yield:

carvedilol dihydrogen phosphate hemihydrate (610309-89-2) → carvedilol dihydrogen phosphate dihydrate (610309-89-2)

Guidance literature:

With water; In acetone; at 10 - 30 ℃;

upstream raw materials:

1-(9H-carbazole-4-oxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanolphosphate

carvedilol

Refernces

• 1、 -. "NOVEL POLYMORPHIC FORMS OF CARVEDILOL DIHYDROGEN PHOSPHATE AND PROCESS FOR PREPARING THE SAME". Page/Page column 5. . Retrieved 2008/12/06.
• 2、 -. "CARVEDILOL PHOSPHATE SESQUIHYDRATE". Page/Page column 9. . Retrieved 2008/06/13.