2-Chloro-6-methoxy-quinazoline

Base Information

• Chemical Name: 2-Chloro-6-methoxy-quinazoline
• CAS No.: 850424-11-2
• Molecular Formula: C9H7ClN2O
• Molecular Weight: 194.62
• Hs Code.: 2933990090
• Mol file: 850424-11-2.mol

Synonyms:2-chloro-6-methoxy quinazoline;Quinazoline,2-chloro-6-methoxy;

Chemical Property of 2-Chloro-6-methoxy-quinazoline

Chemical Property:

• Boiling Point: 294.5±22.0 °C(Predicted)
• PKA: -0.01±0.30(Predicted)
• PSA: 35.01000
• Density: 1.333±0.06 g/cm3(Predicted)
• LogP: 2.29180

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-Chloro-6-methoxyquinazoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-6-methoxy-quinazoline

There total 11 articles about 2-Chloro-6-methoxy-quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

6-methoxyquinazolin-2-ol (850424-10-1) → 2-chloro-6-methoxyquinazoline (850424-11-2)

Guidance literature:

With trichlorophosphate; for 2h; Heating / reflux;

Reference yield: 82.0%

→ 2-chloro-6-methoxyquinazoline (850424-11-2)

Guidance literature:

With trichlorophosphate; for 3h; Reflux;

Reference yield: 71.0%

2,4-dichloro-6-methoxy-quinazoline (105763-77-7) → 2-chloro-6-methoxyquinazoline (850424-11-2)

Guidance literature:

With ammonia; zinc; In dichloromethane; water; at 40 ℃; for 4h; Inert atmosphere;

upstream raw materials:

6-methoxyquinazolin-2-ol

ethyl (2-formyl-4-methoxyphenyl)carbamate

ethyl (2-(1,3-dioxolan-2-yl)-4-methoxyphenyl)carbamate

2-nitro-5-hydroxybenzaldehyde

Downstream raw materials:

C₂₅H₂₅N₅O₂

2-(4-isopropylphenylamino)quinazolin-6-ol

C₁₈H₁₉N₃O

N-(4-isopropylphenyl)-6-methoxyquinazolin-2-amine

Refernces

• 1、 -. "OCTAHYDROPYRROLO [3, 4-c] PYRROLE DERIVATIVES AND USES THEREOF". Paragraph 00215; 00227. . Retrieved 2017/07/04.
• 2、 -. "PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES". . . Retrieved 2016/01/01.