Technology Process of Benzamide,
N-[3-(7-amino-1,2-dihydro-1-methyl-2-oxo-1,6-naphthyridin-3-yl)-4-meth
ylphenyl]-3-(trifluoromethyl)-
There total 16 articles about Benzamide,
N-[3-(7-amino-1,2-dihydro-1-methyl-2-oxo-1,6-naphthyridin-3-yl)-4-meth
ylphenyl]-3-(trifluoromethyl)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium 10% on activated carbon;
In
ethanol;
at 20 ℃;
for 16h;
under 2585.81 Torr;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: potassium hydroxide; water / methanol / 14 h / Heating / reflux
2: hydrogenchloride / 1,4-dioxane / 14 h / Heating / reflux
3: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C
4: sodium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C
5: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C
6: potassium tert-butylate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride / tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 14 h / 100 °C
7: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C / 2585.81 Torr
With
hydrogenchloride; potassium hydroxide; potassium tert-butylate; water; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride;
tris-(dibenzylideneacetone)dipalladium(0); palladium 10% on activated carbon;
In
1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 78 °C
2: manganese(IV) oxide / dichloromethane / 2 h / 20 °C
3: sodium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C
4: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C
5: potassium tert-butylate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride / tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 14 h / 100 °C
6: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C / 2585.81 Torr
With
manganese(IV) oxide; lithium aluminium tetrahydride; potassium tert-butylate; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride;
tris-(dibenzylideneacetone)dipalladium(0); palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
![N-[3-(7-benzylamino-1-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl)-4-methyl-phenyl]-3-trifluoromethyl-benzamide](/Databaselist/images/loading.webp)
