[(R)-3-(Acetylhydroxyamino)-2-hydroxypropyl]phosphonic acid

Base Information

• Chemical Name: [(R)-3-(Acetylhydroxyamino)-2-hydroxypropyl]phosphonic acid
• CAS No.: 73240-15-0
• Molecular Formula: C₅H₁₂NO₆P
• Molecular Weight: 213.127
• Mol file: 73240-15-0.mol

Synonyms:Phosphonic acid,(3-(acetylhydroxyamino)-2-hydroxypropyl)-,(R);(R)-(3-(Acetylhydroxyamino)-2-hydroxypropyl)phosphonic acid;

Chemical Property of [(R)-3-(Acetylhydroxyamino)-2-hydroxypropyl]phosphonic acid

Chemical Property:

• Vapor Pressure: 1.67E-13mmHg at 25°C
• Boiling Point: 531.2°Cat760mmHg
• Flash Point: 275.1°C
• PSA: 128.11000
• Density: 1.639g/cm³
• LogP: -1.23730

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [(R)-3-(Acetylhydroxyamino)-2-hydroxypropyl]phosphonic acid

There total 2 articles about [(R)-3-(Acetylhydroxyamino)-2-hydroxypropyl]phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(N-acetyl-N-hydroxyamino)propylphosphonic acid (66508-32-5) → 3-(N-acetyl-N-hydroxyamino)-2(R)-hydroxypropylphosphonic acid (73240-15-0)

Guidance literature:

With α-ketoglutarate hydroxylase; iron(II) sulfate; ascorbic acid; at 25 ℃; for 24h; Enzymatic reaction;

DOI:10.1039/c1cc13597j

Reference yield:

acetic anhydride (108-24-7) + 3-(N-hydroxyamino)-2(R)-hydroxyaminopropylphosphonic acid (71523-32-5) → 3-(N-acetyl-N-hydroxyamino)-2(R)-hydroxypropylphosphonic acid (73240-15-0)

Guidance literature:

With hydrogenchloride; ammonium hydroxide; Yield given. Multistep reaction; 1.) H₂O, ice-bath, 15 min; 2.) H₂O, RT, 3 h; 3.) H₂O;

DOI:10.1248/cpb.29.646

upstream raw materials:

acetic anhydride

3-(N-hydroxyamino)-2(R)-hydroxyaminopropylphosphonic acid

3-(N-acetyl-N-hydroxyamino)propylphosphonic acid