1-Piperazinecarboxylic acid, 4-[4-[(8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2- yl)amino]phenyl]-2,2-dimethyl-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1-Piperazinecarboxylic acid, 4-[4-[(8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2- yl)amino]phenyl]-2,2-dimethyl-, 1,1-dimethylethyl ester
CAS No.:850628-95-4
Molecular Formula:C30H40N6O3
Molecular Weight:532.686
Hs Code.:

1-Piperazinecarboxylic acid,
4-[4-[(8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-
yl)amino]phenyl]-2,2-dimethyl-, 1,1-dimethylethyl ester

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Chemical Property of 1-Piperazinecarboxylic acid, 4-[4-[(8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2- yl)amino]phenyl]-2,2-dimethyl-, 1,1-dimethylethyl ester

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Technology Process of 1-Piperazinecarboxylic acid, 4-[4-[(8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2- yl)amino]phenyl]-2,2-dimethyl-, 1,1-dimethylethyl ester

There total 5 articles about 1-Piperazinecarboxylic acid, 4-[4-[(8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2- yl)amino]phenyl]-2,2-dimethyl-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 362656-36-8
8-cyclopentyl-2-methanesulfinyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one

: 223786-45-6
4-(4-amino-phenyl)-2,2-dimethyl-piperazine-1-carboxylic acid tert-butyl ester

: 850628-95-4
4-[4-(8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)phenyl]-2,2-dimethylpiperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: In dimethyl sulfoxide; at 100 ℃;
DOI:10.1021/jm049355+

Reference yield:

: 223786-44-5
tert-butyl 2,2-dimethyl-4-(4-nitrophenyl)piperazine-1-carboxylate

: 850628-95-4
4-[4-(8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)phenyl]-2,2-dimethylpiperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Ra-Ni / tetrahydrofuran / 5 h / 20 °C / 2585.74 Torr

2: 36 percent / dimethylsulfoxide / 100 °C

With hydrogen; Ra-Ni; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1021/jm049355+

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 850628-95-4
4-[4-(8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)phenyl]-2,2-dimethylpiperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-diisopropylethylamine / acetonitrile / 14 h / Heating

2: H₂ / Ra-Ni / tetrahydrofuran / 5 h / 20 °C / 2585.74 Torr

3: 36 percent / dimethylsulfoxide / 100 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; Ra-Ni; In tetrahydrofuran; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jm049355+