Carbamic acid, (7-(3,6-dihydro-1(2H)-pyridinyl)-2-oxo-2H-(1,2,4)oxadiazolo(2,3-c)pyrimidin-5-yl)-, 2-methylpropyl ester

Base Information

Chemical Name:Carbamic acid, (7-(3,6-dihydro-1(2H)-pyridinyl)-2-oxo-2H-(1,2,4)oxadiazolo(2,3-c)pyrimidin-5-yl)-, 2-methylpropyl ester
CAS No.:86553-26-6
Molecular Formula:C₁₅H₁₉N₅O₄
Molecular Weight:333.347
Hs Code.:
DSSTox Substance ID:DTXSID70235660
Wikidata:Q83117547

Synonyms:Isobutyl 7-(3,6-dihydro-1(2H)-pyridyl)-2-oxo-2H-(1,2,4)oxadiazolo(2,3-c)pyrimidine-5-carbamate;Carbamic acid, (7-(3,6-dihydro-1(2H)-pyridinyl)-2-oxo-2H-(1,2,4)oxadiazolo(2,3-c)pyrimidin-5-yl)-, 2-methylpropyl ester;86553-26-6;SCHEMBL11193763;DTXSID70235660;LS-49383

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbamic acid, (7-(3,6-dihydro-1(2H)-pyridinyl)-2-oxo-2H-(1,2,4)oxadiazolo(2,3-c)pyrimidin-5-yl)-, 2-methylpropyl ester

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.44g/cm³
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:333.14370410
Heavy Atom Count:24
Complexity:665

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)COC(=O)NC1=NC(=CC2=NC(=O)ON21)N3CCC=CC3

Technology Process of Carbamic acid, (7-(3,6-dihydro-1(2H)-pyridinyl)-2-oxo-2H-(1,2,4)oxadiazolo(2,3-c)pyrimidin-5-yl)-, 2-methylpropyl ester

There total 3 articles about Carbamic acid, (7-(3,6-dihydro-1(2H)-pyridinyl)-2-oxo-2H-(1,2,4)oxadiazolo(2,3-c)pyrimidin-5-yl)-, 2-methylpropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68020-77-9
methyl 5-<3,6-dihydro-1(2H)-pyridyl>-2-oxo-2H-<1,2,4>-oxadiazolo<2,3-a>pyrimidine-7-carbamate

: 86553-26-6
i-butyl 7-<3,6-dihydro-1(2H)-pyridyl>-2H-<1,2,4>oxadiazolo<2,3-a>pyrimidine-5-carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 77.5 percent / 4 N aq. HCl / acetic acid / 10 h / 57 °C

2: 92.5 percent / dimethylformamide / 0.5 h / 135 °C

3: 1.) sodium hydride / 1.) hexane, DMF, r.t., 30 min; 2.) DMF, 20-25 deg C, 1 h

With hydrogenchloride; sodium hydride; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19830660229

Reference yield:

: 74025-90-4
2-amino-6-(methoxycarbonylamino)-4-(1,2,3,4-tetrahydro-1-pyridyl)pyrimidine 1-oxide

: 86553-26-6
i-butyl 7-<3,6-dihydro-1(2H)-pyridyl>-2H-<1,2,4>oxadiazolo<2,3-a>pyrimidine-5-carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 92.5 percent / dimethylformamide / 0.5 h / 135 °C

2: 1.) sodium hydride / 1.) hexane, DMF, r.t., 30 min; 2.) DMF, 20-25 deg C, 1 h

With sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1002/hlca.19830660229

Reference yield:

: Imidazole-1-carboxylic acid isobutyl ester

: 83395-24-8
5-amino-7-<3,6-dihydro-1(2H)-pyridyl>-2H-<1,2,4>-oxadiazolo<2,3-c>pyrimidin-2-one

: 86553-26-6
i-butyl 7-<3,6-dihydro-1(2H)-pyridyl>-2H-<1,2,4>oxadiazolo<2,3-a>pyrimidine-5-carbamate

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1.) hexane, DMF, r.t., 30 min; 2.) DMF, 20-25 deg C, 1 h;
DOI:10.1002/hlca.19830660229