Technology Process of Acetamide, N-[4-[3-amino-4-(methylamino)phenoxy]-2-pyridinyl]-
There total 12 articles about Acetamide, N-[4-[3-amino-4-(methylamino)phenoxy]-2-pyridinyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
at 20 ℃;
for 1h;
DOI:10.1021/ml5002272
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium hydroxide; tetrabutylammomium bromide / water; dichloromethane / 8 h / 20 °C
2.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C
3.1: triethylamine / tetrahydrofuran / 1 h / 0 °C
3.2: 1 h / 0 °C
4.1: sodium azide / water; tetrahydrofuran / 0.75 h / 0 °C
5.1: toluene / 1.5 h / 100 °C
6.1: trifluoroacetic acid / dichloromethane / 3.5 h / 20 °C
7.1: pyridine / 1,4-dioxane / 2 h / 85 °C
8.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C
With
pyridine; sodium azide; palladium 10% on activated carbon; tetrabutylammomium bromide; hydrogen; triethylamine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; toluene;
5.1: |Curtius Rearrangement;
DOI:10.1021/ml5002272
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: potassium tert-butylate / N,N-dimethyl acetamide / 2 h / 20 °C
1.2: 80 °C
2.1: sodium hydroxide; tetrabutylammomium bromide / water; dichloromethane / 8 h / 20 °C
3.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C
4.1: triethylamine / tetrahydrofuran / 1 h / 0 °C
4.2: 1 h / 0 °C
5.1: sodium azide / water; tetrahydrofuran / 0.75 h / 0 °C
6.1: toluene / 1.5 h / 100 °C
7.1: trifluoroacetic acid / dichloromethane / 3.5 h / 20 °C
8.1: pyridine / 1,4-dioxane / 2 h / 85 °C
9.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C
With
pyridine; sodium azide; palladium 10% on activated carbon; potassium tert-butylate; tetrabutylammomium bromide; hydrogen; triethylamine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl acetamide; water; toluene;
6.1: |Curtius Rearrangement;
DOI:10.1021/ml5002272
