2-Aziridinecarboxamide, 2-methyl-3-phenyl-, (2S,3R)-

Base Information

Chemical Name:2-Aziridinecarboxamide, 2-methyl-3-phenyl-, (2S,3R)-
CAS No.:850755-26-9
Molecular Formula:C10H12N2O
Molecular Weight:176.218
Hs Code.:

Synonyms:

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Chemical Property of 2-Aziridinecarboxamide, 2-methyl-3-phenyl-, (2S,3R)-

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Technology Process of 2-Aziridinecarboxamide, 2-methyl-3-phenyl-, (2S,3R)-

There total 4 articles about 2-Aziridinecarboxamide, 2-methyl-3-phenyl-, (2S,3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 850755-23-6
(2R,3R)-(-)-3-azido-2-hydroxy-2-methyl-3-phenylpropionamide

: 850755-26-9
(2S,3R)-(+)-2-methyl-3-phenylaziridine-2-carboxamide

Guidance literature:: (2R,3R)-(-)-3-azido-2-hydroxy-2-methyl-3-phenylpropionamide; With triphenylphosphine; In N,N-dimethyl-formamide; at 20 ℃;

In N,N-dimethyl-formamide; at 100 ℃; for 6h;
DOI:10.1021/jo0482615

Reference yield:

: trans-(+/-)-2-methyl-3-phenyloxiranecarbonitrile

: 850755-26-9
(2S,3R)-(+)-2-methyl-3-phenylaziridine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 45 percent / Rhodococcus sp. AJ₂₇₀ cells; potassium phosphate buffer / H₂O / 7.5 h / 30 °C / pH 7.25

2.1: 90 percent / NaN₃; MgSO₄ / methanol / 24 h / Heating

3.1: PPh₃ / dimethylformamide / 20 °C

3.2: 65 percent / dimethylformamide / 6 h / 100 °C

With sodium azide; potassium phosphate buffer; Rhodococcus sp. AJ₂₇₀ cells; magnesium sulfate; triphenylphosphine; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo0482615

Reference yield:

: 850755-15-6
(2RS,3SR)-2-methyl-3-phenyloxiranecarboxamide

: 850755-26-9
(2S,3R)-(+)-2-methyl-3-phenylaziridine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 41 percent / Rhodococcus sp. AJ₂₇₀ cells; potassium phosphate buffer; acetone / H₂O / 30 °C / pH 7.25

2.1: 90 percent / NaN₃; MgSO₄ / methanol / 24 h / Heating

3.1: PPh₃ / dimethylformamide / 20 °C

3.2: 65 percent / dimethylformamide / 6 h / 100 °C

With sodium azide; potassium phosphate buffer; Rhodococcus sp. AJ₂₇₀ cells; magnesium sulfate; triphenylphosphine; acetone; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo0482615