5-Benzofurancarboxylic acid, 3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2,3-dihydro-4,6-bis(meth oxymethoxy)-2-[[tris(1-methylethyl)silyl]oxy]-, [2-bromo-3-(phenylmethoxy)phenyl]methyl ester

Base Information

Chemical Name:5-Benzofurancarboxylic acid, 3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2,3-dihydro-4,6-bis(meth oxymethoxy)-2-[[tris(1-methylethyl)silyl]oxy]-, [2-bromo-3-(phenylmethoxy)phenyl]methyl ester
CAS No.:850795-90-3
Molecular Formula:C44H65BrO10Si2
Molecular Weight:890.069
Hs Code.:

5-Benzofurancarboxylic acid,
3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2,3-dihydro-4,6-bis(meth
oxymethoxy)-2-[[tris(1-methylethyl)silyl]oxy]-,
[2-bromo-3-(phenylmethoxy)phenyl]methyl ester

Synonyms:

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Chemical Property of 5-Benzofurancarboxylic acid, 3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2,3-dihydro-4,6-bis(meth oxymethoxy)-2-[[tris(1-methylethyl)silyl]oxy]-, [2-bromo-3-(phenylmethoxy)phenyl]methyl ester

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Technology Process of 5-Benzofurancarboxylic acid, 3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2,3-dihydro-4,6-bis(meth oxymethoxy)-2-[[tris(1-methylethyl)silyl]oxy]-, [2-bromo-3-(phenylmethoxy)phenyl]methyl ester

There total 9 articles about 5-Benzofurancarboxylic acid, 3-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-2,3-dihydro-4,6-bis(meth oxymethoxy)-2-[[tris(1-methylethyl)silyl]oxy]-, [2-bromo-3-(phenylmethoxy)phenyl]methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,6-bis-methoxymethoxy-2-triisopropylsilanyloxy-2,3-dihydro-benzofuran-5-carboxylic acid

: 158585-00-3
2-bromo-3-benzyloxy-benzyl alcohol

: 850795-90-3
3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,6-bis-methoxymethoxy-2-triisopropylsilanyloxy-2,3-dihydro-benzofuran-5-carboxylic acid 3-benzyloxy-2-bromo-benzyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 25 ℃; for 0.5h;
DOI:10.1021/ja045520z

Reference yield:

: 850795-82-3
[4-(2,4,6-tris(methoxymethoxy)phenyl)but-3-enyloxy]-tert-butyldimethylsilyl ether

: 850795-90-3
3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,6-bis-methoxymethoxy-2-triisopropylsilanyloxy-2,3-dihydro-benzofuran-5-carboxylic acid 3-benzyloxy-2-bromo-benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: Ag₂O; aq. I₂ / dioxane / 3 h / 0 - 20 °C

2.1: 8.4 g / DIPEA / tetrahydrofuran / 0 - 20 °C

3.1: 93 percent / NBS / CHCl₃ / 1 h

4.1: n-BuLi / pentane; hexane / 0.03 h / -45 °C

4.2: 83 percent / hexane; pentane / 1 h / -45 °C

5.1: NaClO₂; 2-methyl-2-butene; aq. NaH₂PO₄ / tetrahydrofuran; 2-methyl-propan-2-ol / 0.67 h

6.1: 3.5 g / diethyl azodicarboxylate; Ph₃P / tetrahydrofuran / 0.5 h / 25 °C

With sodium chlorite; sodium dihydrogenphosphate; N-Bromosuccinimide; n-butyllithium; 2-methyl-but-2-ene; iodine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; silver(l) oxide; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; hexane; chloroform; tert-butyl alcohol; pentane; 5.1: Pinnick oxidation / 6.1: Mitsunobu reaction;
DOI:10.1021/ja045520z

Reference yield:

: 850795-83-4
4-(tert-butyl-dimethyl-silanyloxy)-2-(2,4,6-tris-methoxymethoxy-phenyl)-butyraldehyde

: 850795-90-3
3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4,6-bis-methoxymethoxy-2-triisopropylsilanyloxy-2,3-dihydro-benzofuran-5-carboxylic acid 3-benzyloxy-2-bromo-benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 8.4 g / DIPEA / tetrahydrofuran / 0 - 20 °C

2.1: 93 percent / NBS / CHCl₃ / 1 h

3.1: n-BuLi / pentane; hexane / 0.03 h / -45 °C

3.2: 83 percent / hexane; pentane / 1 h / -45 °C

4.1: NaClO₂; 2-methyl-2-butene; aq. NaH₂PO₄ / tetrahydrofuran; 2-methyl-propan-2-ol / 0.67 h

5.1: 3.5 g / diethyl azodicarboxylate; Ph₃P / tetrahydrofuran / 0.5 h / 25 °C

With sodium chlorite; sodium dihydrogenphosphate; N-Bromosuccinimide; n-butyllithium; 2-methyl-but-2-ene; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; hexane; chloroform; tert-butyl alcohol; pentane; 4.1: Pinnick oxidation / 5.1: Mitsunobu reaction;
DOI:10.1021/ja045520z