2-Furancarboxamide, N-[(1S)-1-(cyclopentylmethyl)-2-oxo-2-[[(3S)-tetrahydro-2-hydroxy-5-oxo -3-furanyl]amino]ethyl]-5-(3-fluorophenyl)-

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Chemical Name:2-Furancarboxamide, N-[(1S)-1-(cyclopentylmethyl)-2-oxo-2-[[(3S)-tetrahydro-2-hydroxy-5-oxo -3-furanyl]amino]ethyl]-5-(3-fluorophenyl)-
CAS No.:850796-45-1
Molecular Formula:C23H25FN2O6
Molecular Weight:444.46
Hs Code.:

Synonyms:

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Chemical Property of 2-Furancarboxamide, N-[(1S)-1-(cyclopentylmethyl)-2-oxo-2-[[(3S)-tetrahydro-2-hydroxy-5-oxo -3-furanyl]amino]ethyl]-5-(3-fluorophenyl)-

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Technology Process of 2-Furancarboxamide, N-[(1S)-1-(cyclopentylmethyl)-2-oxo-2-[[(3S)-tetrahydro-2-hydroxy-5-oxo -3-furanyl]amino]ethyl]-5-(3-fluorophenyl)-

There total 6 articles about 2-Furancarboxamide, N-[(1S)-1-(cyclopentylmethyl)-2-oxo-2-[[(3S)-tetrahydro-2-hydroxy-5-oxo -3-furanyl]amino]ethyl]-5-(3-fluorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: (3S)-(3-cyclopentyl-(2S)-{[5-(3-fluoro-phenyl)-furan-2-carbonyl]-amino}-propionylamino)-4-oxo-butyric acid t-butyl ester semicarbazone

: 850796-45-1
C₂₃H₂₅FN₂O₆

Guidance literature:: (3S)-(3-cyclopentyl-(2S)-{[5-(3-fluoro-phenyl)-furan-2-carbonyl]-amino}-propionylamino)-4-oxo-butyric acid t-butyl ester semicarbazone; With methoxybenzene; trifluoroacetic acid; In dichloromethane; for 2h;

With formaldehyd; water; acetic acid; In 1,4-dioxane; for 1h;

Reference yield:

: 850796-80-4
Cbz-cyclopentyl alanine dicyclohexylamine salt

: 850796-45-1
C₂₃H₂₅FN₂O₆

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 3 h

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 1.5 h

3.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 2 h

4.1: methoxybenzene; trifluoroacetic acid / dichloromethane / 2 h

4.2: 1 h

With hydrogen; methoxybenzene; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; palladium 10% on activated carbon; In ethanol; dichloromethane;

Reference yield:

: 585-70-6
5-bromo-furan-2-carboxylic acid

: 850796-45-1
C₂₃H₂₅FN₂O₆

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 0.03 h / 200 °C / Microwave irradiation

2.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 2 h

3.1: methoxybenzene; trifluoroacetic acid / dichloromethane / 2 h

3.2: 1 h

With water; sodium carbonate; methoxybenzene; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In dichloromethane;