3-Azabicyclo[3.1.0]hexane-3-carboxylic acid, 6-[[[3-fluoro-4-(4-morpholinyl)phenyl](2-thienylcarbonyl)amino]methyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:3-Azabicyclo[3.1.0]hexane-3-carboxylic acid, 6-[[[3-fluoro-4-(4-morpholinyl)phenyl](2-thienylcarbonyl)amino]methyl]-, 1,1-dimethylethyl ester
CAS No.:850808-46-7
Molecular Formula:C26H32FN3O4S
Molecular Weight:501.622
Hs Code.:

3-Azabicyclo[3.1.0]hexane-3-carboxylic acid,
6-[[[3-fluoro-4-(4-morpholinyl)phenyl](2-thienylcarbonyl)amino]methyl]-,
1,1-dimethylethyl ester

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Chemical Property of 3-Azabicyclo[3.1.0]hexane-3-carboxylic acid, 6-[[[3-fluoro-4-(4-morpholinyl)phenyl](2-thienylcarbonyl)amino]methyl]-, 1,1-dimethylethyl ester

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Technology Process of 3-Azabicyclo[3.1.0]hexane-3-carboxylic acid, 6-[[[3-fluoro-4-(4-morpholinyl)phenyl](2-thienylcarbonyl)amino]methyl]-, 1,1-dimethylethyl ester

There total 2 articles about 3-Azabicyclo[3.1.0]hexane-3-carboxylic acid, 6-[[[3-fluoro-4-(4-morpholinyl)phenyl](2-thienylcarbonyl)amino]methyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5271-67-0
2-Thiophenecarbonyl chloride

: 850808-45-6
6-[(3-fluoro-4-morpholin-4-yl-phenylamino)-methyl]-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester

: 850808-46-7
6-{[(3-fluoro-4-morpholin-4-yl-phenyl)-(thiophene-2-carbonyl)-amino]-methyl}-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 20 ℃; for 2h;

Reference yield:

: 912468-67-8
tert-butyl 6-formyl-3-azabicyclo[3.1.0]hexane-3-carboxylate

: 850808-46-7
6-{[(3-fluoro-4-morpholin-4-yl-phenyl)-(thiophene-2-carbonyl)-amino]-methyl}-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium cyanoborohydride; acetic acid / methanol / 1.5 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 2 h / 20 °C

With sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; 1,2-dichloro-ethane;