Technology Process of Benzoic acid, 2,4,6-trimethyl-,
(3R,5S,6E)-5-hydroxy-8-methoxy-3-methyl-8-oxo-6-octenyl ester
There total 1 articles about Benzoic acid, 2,4,6-trimethyl-,
(3R,5S,6E)-5-hydroxy-8-methoxy-3-methyl-8-oxo-6-octenyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(S)-5-formyl-3-methylpentyl 2,4,6-trimethylbenzoate;
With
Nitrosobenzene; D-Prolin;
In
dimethyl sulfoxide;
for 0.5h;
cooling;
Methyl diethylphosphonoacetate;
With
1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride;
In
dimethyl sulfoxide; acetonitrile;
at -15 ℃;
for 0.25h;
With
ammonium chloride;
In
methanol; dimethyl sulfoxide; acetonitrile;
at 20 ℃;
for 48h;
DOI:10.1021/ja050064f
- Guidance literature:
-
With
1H-imidazole; dmap;
In
N,N-dimethyl-formamide;
for 12h;
DOI:10.1021/ja050064f
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 97 percent / imidazole; DMAP / dimethylformamide / 12 h
2.1: 96 percent / diisobutylaluminum hydride / hexane; diethyl ether / 0.5 h / -78 °C
3.1: Dess-Martin periodinane / CH2Cl2 / 0.67 h
4.1: L-proline / dimethylsulfoxide / 5 h / 40 °C
4.2: 910 mg / pyridine; DMAP / dimethylsulfoxide / 0.25 h / 0 °C
With
1H-imidazole; dmap; diisobutylaluminium hydride; Dess-Martin periodane; L-proline;
In
diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
4.1: intramolecular Michael addition;
DOI:10.1021/ja050064f
