Ethyl 6-chloro-5-(trifluoroMethyl)picolinate

Base Information

• Chemical Name: Ethyl 6-chloro-5-(trifluoroMethyl)picolinate
• CAS No.: 850864-57-2
• Molecular Formula: C9H7ClF3NO2
• Molecular Weight: 253.60600
• Mol file: 850864-57-2.mol

Synonyms:ethyl 6-chloro-5-(trifluoromethyl)pyridine-2-carboxylate;

Chemical Property of Ethyl 6-chloro-5-(trifluoroMethyl)picolinate

Chemical Property:

• PSA: 39.19000
• LogP: 2.93050
• Storage Temp.: 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

Ethyl6-chloro-5-(trifluoromethyl)-2-pyridinecarboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 6-chloro-5-(trifluoroMethyl)picolinate

There total 1 articles about Ethyl 6-chloro-5-(trifluoroMethyl)picolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.3%

6-hydroxy-5-trifluoromethyl-pyridine-2-carboxylic acid ethyl ester (855911-28-3) → 6-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid ethyl ester (850864-57-2)

Guidance literature:

With O-phenyl phosphorodichloridate; at 170 ℃; for 0.5h;

Reference yield: 87.8%

6-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid ethyl ester (850864-57-2) + Trimethylboroxine (823-96-1) → 6-methyl-5-trifluoromethyl-pyridine-2-carboxylic acid ethyl ester (855911-75-0)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; for 2.5h; Heating / reflux;

Reference yield:

6-chloro-5-trifluoromethyl-pyridine-2-carboxylic acid ethyl ester (850864-57-2) + tri-n-butyl(vinyl)tin (7486-35-3) → 5-trifluoromethyl-6-vinyl-pyridine-2-carboxylic acid ethyl ester

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 95 ℃; for 20h;

upstream raw materials:

6-hydroxy-5-trifluoromethyl-pyridine-2-carboxylic acid ethyl ester

Downstream raw materials:

6-methyl-5-trifluoromethyl-pyridine-2-carboxylic acid ethyl ester

Refernces

• 1、 -. "PICOLINYLPYRAZOLES AS HERBICIDES". Page/Page column 72-73. . Retrieved 2010/02/12.