2H-1,4-BENZODIAZEPIN-2-ONE, 1,3-DIHYDRO-7-CHLORO-5-(o-FLUOROPHENYL)-3-HYDROXY-

Base Information

Chemical Name:2H-1,4-BENZODIAZEPIN-2-ONE, 1,3-DIHYDRO-7-CHLORO-5-(o-FLUOROPHENYL)-3-HYDROXY-
CAS No.:17617-60-6
Molecular Formula:C₁₅H₁₀ClFN₂O₂
Molecular Weight:304.708
Hs Code.:
DSSTox Substance ID:DTXSID50874637
Nikkaji Number:J431.359C
ChEMBL ID:CHEMBL64755
Mol file:17617-60-6.mol

Synonyms:3-hydroxy-N-desalkyl-2-oxoquazepam;CM 40095;HDOQ;Ro 7-5205

Suppliers and Price of 2H-1,4-BENZODIAZEPIN-2-ONE, 1,3-DIHYDRO-7-CHLORO-5-(o-FLUOROPHENYL)-3-HYDROXY-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(+/-)-7-CHLORO-3-HYDROXY-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-2H-1,4-BENZODIAZEPINE-2-ONE 95.00%
5MG
$ 497.63

Total 27 raw suppliers

Chemical Property of 2H-1,4-BENZODIAZEPIN-2-ONE, 1,3-DIHYDRO-7-CHLORO-5-(o-FLUOROPHENYL)-3-HYDROXY-

Chemical Property:

Vapor Pressure:4.18E-11mmHg at 25°C
Boiling Point:507.1°Cat760mmHg
Flash Point:260.5°C
PSA：61.69000
Density:1.48g/cm³
LogP:2.16060
XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:304.0414834
Heavy Atom Count:21
Complexity:445

Purity/Quality:

98% Min ^*data from raw suppliers

(+/-)-7-CHLORO-3-HYDROXY-5-(2-FLUOROPHENYL)-1,3-DIHYDRO-2H-1,4-BENZODIAZEPINE-2-ONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O)F
Use Description The chemical compound 7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one belongs to the benzodiazepine class and is used primarily in the field of pharmaceuticals. In medicine, it serves as an important active ingredient in the formulation of anxiolytic and sedative medications, contributing to the management of anxiety disorders and sleep disturbances. These drugs work by modulating the central nervous system to reduce anxiety and induce relaxation, making them valuable tools in psychiatry and neurology. Their significance extends to various medical fields where managing anxiety and promoting calmness are essential, highlighting their pivotal role in pharmaceuticals for improving mental health and well-being.

Technology Process of 2H-1,4-BENZODIAZEPIN-2-ONE, 1,3-DIHYDRO-7-CHLORO-5-(o-FLUOROPHENYL)-3-HYDROXY-

There total 3 articles about 2H-1,4-BENZODIAZEPIN-2-ONE, 1,3-DIHYDRO-7-CHLORO-5-(o-FLUOROPHENYL)-3-HYDROXY- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89722-88-3
Trifluoro-acetic acid 7-chloro-5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl ester

: 17617-60-6,40762-01-4
7-chloro-1,3-dihydro-3-hydroxy-5-(2-fluorophenyl)-2H-1,4-benzodiazepine-2-one

Guidance literature:: With sodium hydrogencarbonate; In ethanol; at 25 ℃; for 18h; Yield given;
DOI:10.1016/S0022-1139(00)85140-4

Reference yield:

: 7435-12-3
7-Chloro-5-(2-fluoro-phenyl)-4-oxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one

: 17617-60-6,40762-01-4
7-chloro-1,3-dihydro-3-hydroxy-5-(2-fluorophenyl)-2H-1,4-benzodiazepine-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.5 h

2: aq. 5 percent sodium bicarbonate / ethanol / 18 h / 25 °C

With sodium hydrogencarbonate; In ethanol;
DOI:10.1016/S0022-1139(00)85140-4