3-Oxazolidinecarboxylic acid, 2,2-dimethyl-4-[(2R)-3-[[(phenylmethoxy)carbonyl]amino]-2-[[tris(1-meth ylethyl)silyl]oxy]propyl]-, 1,1-dimethylethyl ester, (4S)-

Base Information

Chemical Name:3-Oxazolidinecarboxylic acid, 2,2-dimethyl-4-[(2R)-3-[[(phenylmethoxy)carbonyl]amino]-2-[[tris(1-meth ylethyl)silyl]oxy]propyl]-, 1,1-dimethylethyl ester, (4S)-
CAS No.:850996-90-6
Molecular Formula:C30H52N2O6Si
Molecular Weight:564.838
Hs Code.:

3-Oxazolidinecarboxylic acid,
2,2-dimethyl-4-[(2R)-3-[[(phenylmethoxy)carbonyl]amino]-2-[[tris(1-meth
ylethyl)silyl]oxy]propyl]-, 1,1-dimethylethyl ester, (4S)-

Synonyms:

Suppliers and Price of 3-Oxazolidinecarboxylic acid, 2,2-dimethyl-4-[(2R)-3-[[(phenylmethoxy)carbonyl]amino]-2-[[tris(1-meth ylethyl)silyl]oxy]propyl]-, 1,1-dimethylethyl ester, (4S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-Oxazolidinecarboxylic acid, 2,2-dimethyl-4-[(2R)-3-[[(phenylmethoxy)carbonyl]amino]-2-[[tris(1-meth ylethyl)silyl]oxy]propyl]-, 1,1-dimethylethyl ester, (4S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Oxazolidinecarboxylic acid, 2,2-dimethyl-4-[(2R)-3-[[(phenylmethoxy)carbonyl]amino]-2-[[tris(1-meth ylethyl)silyl]oxy]propyl]-, 1,1-dimethylethyl ester, (4S)-

There total 9 articles about 3-Oxazolidinecarboxylic acid, 2,2-dimethyl-4-[(2R)-3-[[(phenylmethoxy)carbonyl]amino]-2-[[tris(1-meth ylethyl)silyl]oxy]propyl]-, 1,1-dimethylethyl ester, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13139-17-8
N-(Benzyloxycarbonyloxy)succinimide

: 909415-68-5
C₂₂H₄₆N₂O₄Si

: 850996-90-6
(4S)-[(2R)-3-benzyloxycarbonylamino-2-triisopropylsilanyloxypropyl]-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 70h;

Reference yield:

: 4-(3-amino-2-triisopropylsilanyloxy-propyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 13139-17-8
N-(Benzyloxycarbonyloxy)succinimide

: 850996-90-6
(4S)-[(2R)-3-benzyloxycarbonylamino-2-triisopropylsilanyloxypropyl]-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 70h;
DOI:10.1021/ol0503182

Reference yield:

: 850996-87-1
(4S)-4-[2-(1-methoxy-1-methylethoxy)ethyl]-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

: 850996-90-6
(4S)-[(2R)-3-benzyloxycarbonylamino-2-triisopropylsilanyloxypropyl]-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 14.64 g / silica gel / CH₂Cl₂; H₂O / 72 h / 20 °C

2.1: 97 percent / DMSO; oxalyl chloride; Et₃N / CH₂Cl₂ / 1.5 h / -60 - 20 °C

3.1: Cu(OAc)2*H₂O; 2,2-bis[(3aS,8aR)-3a,8,8a-3H-indeno[3,2-d]oxazol-2yl]propane / ethanol / 120 h / 20 °C

3.2: 2,6-lutidine / CH₂Cl₂ / 16.5 h / 0 - 20 °C

3.3: HCO₂NH₄ / Pd/C / methanol / 24 h / 20 °C

4.1: 2.252 g / Et₃N / CH₂Cl₂ / 70 h / 20 °C

With copper diacetate; oxalyl dichloride; 2,2-bis[(3aS,8aR)-3a,8,8a-3H-indeno[3,2-d]oxazol-2yl]propane; silica gel; dimethyl sulfoxide; triethylamine; In ethanol; dichloromethane; water; 2.1: Swern oxidation / 3.1: Henry reaction;
DOI:10.1021/ol0503182