2,3-Diphenylimidazo[1,2-a]pyridine

Base Information

• Chemical Name: 2,3-Diphenylimidazo[1,2-a]pyridine
• CAS No.: 85102-26-7
• Molecular Formula: C19H14N2
• Molecular Weight: 270.334
• DSSTox Substance ID: DTXSID401320522
• Nikkaji Number: J1.475.787B
• ChEMBL ID: CHEMBL1719415
• Mol file: 85102-26-7.mol

Synonyms:2,3-diphenylimidazo[1,2-a]pyridine;85102-26-7;Oprea1_371241;Oprea1_393113;MLS001179151;SCHEMBL5347018;CHEMBL1719415;DTXSID401320522;HMS2796M07;MFCD00772532;STL228073;AKOS001020988;AS-38303;SMR000476084;CS-0326269;2,3-Diphenylimidazo[1,2-a]pyridine, AldrichCPR;Z56813659

Chemical Property of 2,3-Diphenylimidazo[1,2-a]pyridine

Chemical Property:

• Melting Point: 150 - 152 °C
• PSA: 17.30000
• LogP: 4.66830
• XLogP3: 5.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 270.115698455
• Heavy Atom Count: 21
• Complexity: 331

Purity/Quality:

99% ^*data from raw suppliers

2,3-Diphenylimidazo[1,2-a]pyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=C(N3C=CC=CC3=N2)C4=CC=CC=C4

Technology Process of 2,3-Diphenylimidazo[1,2-a]pyridine

There total 60 articles about 2,3-Diphenylimidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-phenylimidazo[1,2-a]pyridine (4105-21-9) + phenol (108-95-2,27073-41-2) → 2,3-diphenyl-1H-imidazo[1,2-a]pyridine (85102-26-7)

Guidance literature:

With palladium diacetate; In isopropyl alcohol; at 20 - 25 ℃; for 4h; Irradiation;

Reference yield: 96.0%

3-iodo-2-phenylimidazo[1,2-α]pyridine (64413-90-7) + phenylboronic acid (98-80-6) → 2,3-diphenyl-1H-imidazo[1,2-a]pyridine (85102-26-7)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,4-dioxane; water; Reflux;

DOI:10.1039/d0gc00137f

Reference yield: 95.0%

bromobenzene (108-86-1,52753-63-6) + 2-phenylimidazo[1,2-a]pyridine (4105-21-9) → 2,3-diphenyl-1H-imidazo[1,2-a]pyridine (85102-26-7)

Guidance literature:

With palladium diacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; Trimethylacetic acid; In N,N-dimethyl acetamide; at 100 ℃; for 16h; Inert atmosphere; Sealed vessel;

DOI:10.1016/j.tetlet.2011.11.015

upstream raw materials:

2-aminopyridine

Desyl chloride

2-Morpholinomethyl-4,5-diphenyl-1-(2-propynyl)-imidazole

3-iodo-2-phenylimidazo[1,2-α]pyridine