1H-Pyrrol-1-yloxy, 3-[[[2-[4-[(2-butyl-3-benzofuranyl)carbonyl]-2,6-diiodophenoxy]ethyl]ethyl amino]methyl]-2,5-dihydro-2,2,5,5-tetramethyl-

Base Information

• Chemical Name: 1H-Pyrrol-1-yloxy, 3-[[[2-[4-[(2-butyl-3-benzofuranyl)carbonyl]-2,6-diiodophenoxy]ethyl]ethyl amino]methyl]-2,5-dihydro-2,2,5,5-tetramethyl-
• CAS No.: 851025-45-1
• Molecular Formula: C32H39I2N2O4
• Molecular Weight: 769.482
• Mol file: 851025-45-1.mol

Synonyms:

Chemical Property of 1H-Pyrrol-1-yloxy, 3-[[[2-[4-[(2-butyl-3-benzofuranyl)carbonyl]-2,6-diiodophenoxy]ethyl]ethyl amino]methyl]-2,5-dihydro-2,2,5,5-tetramethyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Pyrrol-1-yloxy, 3-[[[2-[4-[(2-butyl-3-benzofuranyl)carbonyl]-2,6-diiodophenoxy]ethyl]ethyl amino]methyl]-2,5-dihydro-2,2,5,5-tetramethyl-

There total 3 articles about 1H-Pyrrol-1-yloxy, 3-[[[2-[4-[(2-butyl-3-benzofuranyl)carbonyl]-2,6-diiodophenoxy]ethyl]ethyl amino]methyl]-2,5-dihydro-2,2,5,5-tetramethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

C14H27N2O4S (851025-42-8) + 2-n-butyl-3-(3',5'-diiodo-4'-hydroxybenzoyl)benzofuran (1951-26-4) → 2-butyl-3-(3,5-diiodo-4-{2-[N-ethyl,N-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-ylmethyl)amino]ethyl}oxybenzoyl)benzofuran (851025-45-1)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In acetone; for 24h; Heating;

DOI:10.1016/j.bmc.2005.01.028

Reference yield:

3-{[ethyl-(2-hydroxyethyl)-amino]-methyl}-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-1-yloxyl (851025-44-0) → 2-butyl-3-(3,5-diiodo-4-{2-[N-ethyl,N-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-ylmethyl)amino]ethyl}oxybenzoyl)benzofuran (851025-45-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / triethylamine / CH₂Cl₂ / 1 h / 0 - 20 °C

2: 39 percent / K₂CO₃; 18-crown-6 / acetone / 24 h / Heating

With 18-crown-6 ether; potassium carbonate; triethylamine; In dichloromethane; acetone;

DOI:10.1016/j.bmc.2005.01.028

Reference yield:

3-(bromomethyl)-2,5-dihydro-2,2,5,5-tetramethyl-1H-pyrrol-1-oxyl (76893-32-8) → 2-butyl-3-(3,5-diiodo-4-{2-[N-ethyl,N-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-ylmethyl)amino]ethyl}oxybenzoyl)benzofuran (851025-45-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / K₂CO₃ / CHCl₃ / 4 h / Heating

2: 66 percent / triethylamine / CH₂Cl₂ / 1 h / 0 - 20 °C

3: 39 percent / K₂CO₃; 18-crown-6 / acetone / 24 h / Heating

With 18-crown-6 ether; potassium carbonate; triethylamine; In dichloromethane; chloroform; acetone;

DOI:10.1016/j.bmc.2005.01.028

upstream raw materials:

C₁₄H₂₇N₂O₄S

2-n-butyl-3-(3',5'-diiodo-4'-hydroxybenzoyl)benzofuran

3-{[ethyl-(2-hydroxyethyl)-amino]-methyl}-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-1-yloxyl

3-(bromomethyl)-2,5-dihydro-2,2,5,5-tetramethyl-1H-pyrrol-1-oxyl