Chemical Property of Pseudolaric acid B
Chemical Property:
- Vapor Pressure:1.2E-16mmHg at 25°C
- Melting Point:166°C
- Refractive Index:1.4480 (estimate)
- Boiling Point:613.8oC at 760 mmHg
- PKA:4.52±0.19(Predicted)
- Flash Point:208.8oC
- PSA：116.20000
- Density:1.29g/cm3
- LogP:2.87060
- Storage Temp.:2-8°C
- Solubility.:methanol: soluble1mg/mL, clear, colorless
- XLogP3:2.3
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:8
- Rotatable Bond Count:7
- Exact Mass:432.17841785
- Heavy Atom Count:31
- Complexity:913
- Purity/Quality:
-
99%, *data from raw suppliers
Pseudolaric Acid B *data from reagent suppliers
Safty Information:
- Pictogram(s):
T
- Hazard Codes:T
- Statements:
25-62
- Safety Statements:
36/37-45-24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC(=CC=CC1(C2CCC3(C2(CCC(=CC3)C(=O)OC)OC(=O)C)C(=O)O1)C)C(=O)O
- Isomeric SMILES:C/C(=C\C=C\[C@@]1([C@@H]2CC[C@@]3([C@@]2(CCC(=CC3)C(=O)OC)OC(=O)C)C(=O)O1)C)/C(=O)O
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Description
Pseudolaric acid B (PAB) is a diterpene acid isolated from the bark of P. kaempferi, a traditional Chinese medicinal plant. It has reported antifungal activities, consistent with its traditional use in the treatment of dermatological fungal infections. Moreover, PAB has diverse effects that are relevant to cancer therapy, including inducing apoptosis of cancer cells (IC50 = ~1 μM), preventing angiogenesis, and inhibiting tumor growth in vivo.
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Uses
(-)-Pseudolaric Acid B is a diterpenoid posessing an immunomodulatory effect. It acts as an immunosuppressant in vitro/vivo however does show some cytotoxicity. Anti-tumor agent as well.
