1-Pyrrolidinecarboxylic acid, 2-formyl-2-methyl-, 1,1-dimethylethyl ester, (2S)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-formyl-2-methyl-, 1,1-dimethylethyl ester, (2S)-
CAS No.:851028-60-9
Molecular Formula:C₁₁H₁₉NO₃
Molecular Weight:213.277
Hs Code.:

Synonyms:(S)-(+)-N-Boc-2-prolinal;tert-butyl (S)-2-formyl-2-methylpyrrolidine-1-carboxylate;(S)-2-formyl-2-methyl-pyrrolidine-1-carboxylic acid tert-butyl ester;

Suppliers and Price of 1-Pyrrolidinecarboxylic acid, 2-formyl-2-methyl-, 1,1-dimethylethyl ester, (2S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
Tert-butyl(2S)-2-formyl-2-methylpyrrolidine-1-carboxylate
1g
$ 1309.00

Total 5 raw suppliers

Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-formyl-2-methyl-, 1,1-dimethylethyl ester, (2S)-

Chemical Property:

Boiling Point:281.2±33.0 °C(Predicted)
PSA：46.61000
Density:1.111±0.06 g/cm3(Predicted)
LogP:1.91280

Purity/Quality:

97% ^*data from raw suppliers

Tert-butyl(2S)-2-formyl-2-methylpyrrolidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-Pyrrolidinecarboxylic acid, 2-formyl-2-methyl-, 1,1-dimethylethyl ester, (2S)-

There total 7 articles about 1-Pyrrolidinecarboxylic acid, 2-formyl-2-methyl-, 1,1-dimethylethyl ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1339022-10-4
tert-butyl (2S)-2-(hydroxymethyl)-2-methylpyrrolidine-1-carboxylate

: 851028-60-9
(S)-tert-butyl 2-formyl-2-methylpyrrolidine-1-carboxylate

Guidance literature:: tert-butyl (2S)-2-(hydroxymethyl)-2-methylpyrrolidine-1-carboxylate; With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 6h;

With sodium hydroxide; In diethyl ether; dichloromethane; water; for 0.25h;
DOI:10.1021/ol202381m

Reference yield: 47.0%

: 851028-60-9
(S)-tert-butyl 2-formyl-2-methylpyrrolidine-1-carboxylate

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃;

Reference yield:

: 42856-71-3
(S)-2-methylpyrrolidine-2-carboxylic acid

: 851028-60-9
(S)-tert-butyl 2-formyl-2-methylpyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetramethyl ammoniumhydroxide / acetonitrile

2.1: borane-THF / tetrahydrofuran / 1 h / Reflux

3.1: Dess-Martin periodane / dichloromethane / 6 h / 0 - 20 °C

3.2: 0.25 h

With borane-THF; tetramethyl ammoniumhydroxide; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; acetonitrile; 3.1: Dess-Martin oxidation;
DOI:10.1021/ol202381m