5-BENZYL-1,3,4-THIADIAZOLE-2-THIOL

Base Information

• Chemical Name: 5-BENZYL-1,3,4-THIADIAZOLE-2-THIOL
• CAS No.: 85103-31-7
• Molecular Formula: C9H8N2S2
• Molecular Weight: 208.308
• Hs Code.: 2934999090
• Mol file: 85103-31-7.mol

Synonyms:RARECHEM BG FB 0149;5-BENZYL-1,3,4-THIADIAZOL-2-YL HYDROSULFIDE;5-p-tolyl-1,3,4-thiadiazole-2(3H)-thione;

Chemical Property of 5-BENZYL-1,3,4-THIADIAZOLE-2-THIOL

Chemical Property:

• PSA: 92.82000
• LogP: 2.41760
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BENZYL-1,3,4-THIADIAZOLE-2-THIOL

There total 3 articles about 5-BENZYL-1,3,4-THIADIAZOLE-2-THIOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

potassium 3-p-toluoyldithiocarbazate (38499-94-4) → 5-p-tolyl-1,3,4-thiadiazole-2(3H)-thione (85103-31-7)

Guidance literature:

With sulfuric acid; at 0 - 5 ℃; for 0.0833333h; Yield given;

DOI:10.1071/CH9842385

Reference yield:

p-toluic hydrazide (3619-22-5) → 5-p-tolyl-1,3,4-thiadiazole-2(3H)-thione (85103-31-7)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / ethanol / 0.5 h

2: conc. H₂SO₄ / 0.08 h / 0 - 5 °C

With potassium hydroxide; sulfuric acid; In ethanol;

DOI:10.1071/CH9842385

Reference yield:

carbon disulfide (75-15-0,12122-00-8) + p-toluic hydrazide (3619-22-5) → 5-p-tolyl-1,3,4-thiadiazole-2(3H)-thione (85103-31-7)

Guidance literature:

carbon disulfide; p-toluic hydrazide; With potassium hydroxide; In ethanol;

With hydrogenchloride;

DOI:10.1007/s11164-021-04510-x

upstream raw materials:

potassium 3-p-toluoyldithiocarbazate

p-toluic hydrazide

carbon disulfide

Downstream raw materials:

5-p-methylphenyl-2-phenylmercapto-1,3,4-thiadiazole

3-(Quinolin-5-ylaminomethyl)-5-p-tolyl-3H-[1,3,4]thiadiazole-2-thione

3-(Quinolin-8-yloxymethyl)-5-p-tolyl-3H-[1,3,4]thiadiazole-2-thione

3-(Benzylamino-methyl)-5-p-tolyl-3H-[1,3,4]thiadiazole-2-thione

Refernces

• 1、 Wang, Xiu,Duan, Wen-Gui,Lin, Gui-Shan,Chen, Ming,Lei, Fu-Hou. "Synthesis, antifungal activity and 3D-QSAR study of novel nopol-based 1,3,4-thiadiazole–thioether compounds". . p. 4029 - 4049. Retrieved 2021/06/21.