5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[[4-[[[[(2R)-2-amino-2-carboxyethyl]thio]acetyl]amino]phenyl]thio]meth yl]-7-[[[[(1,1-dimethylethoxy)carbonyl]amino]acetyl]amino]-8-oxo-, 2-(diphenylmethyl) ester, (6R,7R)-

Base Information

Chemical Name:5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[[4-[[[[(2R)-2-amino-2-carboxyethyl]thio]acetyl]amino]phenyl]thio]meth yl]-7-[[[[(1,1-dimethylethoxy)carbonyl]amino]acetyl]amino]-8-oxo-, 2-(diphenylmethyl) ester, (6R,7R)-
CAS No.:851047-91-1
Molecular Formula:C39H43N5O9S3
Molecular Weight:821.997
Hs Code.:

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,
3-[[[4-[[[[(2R)-2-amino-2-carboxyethyl]thio]acetyl]amino]phenyl]thio]meth
yl]-7-[[[[(1,1-dimethylethoxy)carbonyl]amino]acetyl]amino]-8-oxo-,
2-(diphenylmethyl) ester, (6R,7R)-

Synonyms:

Suppliers and Price of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[[4-[[[[(2R)-2-amino-2-carboxyethyl]thio]acetyl]amino]phenyl]thio]meth yl]-7-[[[[(1,1-dimethylethoxy)carbonyl]amino]acetyl]amino]-8-oxo-, 2-(diphenylmethyl) ester, (6R,7R)-

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Chemical Property of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[[4-[[[[(2R)-2-amino-2-carboxyethyl]thio]acetyl]amino]phenyl]thio]meth yl]-7-[[[[(1,1-dimethylethoxy)carbonyl]amino]acetyl]amino]-8-oxo-, 2-(diphenylmethyl) ester, (6R,7R)-

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Technology Process of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[[4-[[[[(2R)-2-amino-2-carboxyethyl]thio]acetyl]amino]phenyl]thio]meth yl]-7-[[[[(1,1-dimethylethoxy)carbonyl]amino]acetyl]amino]-8-oxo-, 2-(diphenylmethyl) ester, (6R,7R)-

There total 5 articles about 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[[4-[[[[(2R)-2-amino-2-carboxyethyl]thio]acetyl]amino]phenyl]thio]meth yl]-7-[[[[(1,1-dimethylethoxy)carbonyl]amino]acetyl]amino]-8-oxo-, 2-(diphenylmethyl) ester, (6R,7R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 935278-19-6
(6R,7R)-7-(2-tert-Butoxycarbonylamino-acetylamino)-3-chloromethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

: 851047-91-1
(6R,7R)-3-{4-[2-((R)-2-Amino-2-carboxy-ethylsulfanyl)-acetylamino]-phenylsulfanylmethyl}-7-(2-tert-butoxycarbonylamino-acetylamino)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NaI / acetone / 1 h / 20 °C

2: 0.178 g / NaHCO₃ / dimethylformamide / 2 h / 20 °C

3: 85 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 2 h / 20 °C

4: 80 percent / 2,6-lutidine / methanol / 8 h / 20 °C

With 2,6-dimethylpyridine; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ja042829+

Reference yield:

: (6R,7R)-7-(2-tert-Butoxycarbonylamino-acetylamino)-3-iodomethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

: 851047-91-1
(6R,7R)-3-{4-[2-((R)-2-Amino-2-carboxy-ethylsulfanyl)-acetylamino]-phenylsulfanylmethyl}-7-(2-tert-butoxycarbonylamino-acetylamino)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 0.178 g / NaHCO₃ / dimethylformamide / 2 h / 20 °C

2: 85 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 2 h / 20 °C

3: 80 percent / 2,6-lutidine / methanol / 8 h / 20 °C

With 2,6-dimethylpyridine; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja042829+

Reference yield:

: 851047-89-7
(6R,7R)-3-(4-Amino-phenylsulfanylmethyl)-7-(2-tert-butoxycarbonylamino-acetylamino)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

: 851047-91-1
(6R,7R)-3-{4-[2-((R)-2-Amino-2-carboxy-ethylsulfanyl)-acetylamino]-phenylsulfanylmethyl}-7-(2-tert-butoxycarbonylamino-acetylamino)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 2 h / 20 °C

2: 80 percent / 2,6-lutidine / methanol / 8 h / 20 °C

With 2,6-dimethylpyridine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1021/ja042829+