Indeno[2,1-e]indazol-7(3H)-one, 8,9,9a,10-tetrahydro-6-[4-(methoxymethoxy)phenyl]-3-[(4-methylphenyl) sulfonyl]-9a-(phenylmethyl)-

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Chemical Name:Indeno[2,1-e]indazol-7(3H)-one, 8,9,9a,10-tetrahydro-6-[4-(methoxymethoxy)phenyl]-3-[(4-methylphenyl) sulfonyl]-9a-(phenylmethyl)-
CAS No.:851107-82-9
Molecular Formula:C36H32N2O5S
Molecular Weight:604.726
Hs Code.:

Synonyms:

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Chemical Property of Indeno[2,1-e]indazol-7(3H)-one, 8,9,9a,10-tetrahydro-6-[4-(methoxymethoxy)phenyl]-3-[(4-methylphenyl) sulfonyl]-9a-(phenylmethyl)-

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Technology Process of Indeno[2,1-e]indazol-7(3H)-one, 8,9,9a,10-tetrahydro-6-[4-(methoxymethoxy)phenyl]-3-[(4-methylphenyl) sulfonyl]-9a-(phenylmethyl)-

There total 12 articles about Indeno[2,1-e]indazol-7(3H)-one, 8,9,9a,10-tetrahydro-6-[4-(methoxymethoxy)phenyl]-3-[(4-methylphenyl) sulfonyl]-9a-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 851107-81-8
9a-benzyl-6-bromo-3-[(4-methylphenyl)sulfonyl]-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one

: tributyl-(4-methoxymethoxyphenyl)-stannane

: 851107-82-9
9a-benzyl-6-[4-(methoxymethoxy)phenyl]-3-[(4-methylphenyl)sulfonyl]-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 100 ℃; for 24h;
DOI:10.1021/jm060516e

Reference yield:

: 429682-70-2
N-(4-methyl-1-oxo-2,3-dihydro-1H-inden-5-yl)acetamide

: 851107-82-9
9a-benzyl-6-[4-(methoxymethoxy)phenyl]-3-[(4-methylphenyl)sulfonyl]-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: 74 percent / NaOMe / ethanol; methanol / 6 h / 20 °C

2.1: 77 percent / H₂ / Pd/C / ethyl acetate; methanol / 1.5 h / 40 °C / atmospheric pressure

3.1: sodium methoxide / methanol / 19 h / 20 °C

4.1: 1.18 g / pyrrolidine; HOAc / tetrahydrofuran / 1.25 h / 100 °C

5.1: 100 percent / NaHCO₃; Br₂ / CH₂Cl₂ / 0.25 h / 0 °C

6.1: 75 percent / sodium methoxide / ethanol; methanol / 6.5 h / 80 °C

7.1: nitrosium tetrafluoroborate / CH₂Cl₂ / 1 h / -35 - 4 °C

7.2: 35 percent / potassium acetate; dibenzo-18-crown-6 / CH₂Cl₂ / 1 h / -35 - 20 °C

8.1: 25 percent / 4-(dimethylamino)-pyridine / CH₂Cl₂ / 2 h / 0 - 20 °C

9.1: 66 percent / tetrakis(triphenylphosphine)-palladium⁽⁰⁾ / toluene / 24 h / 100 °C

With pyrrolidine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; bromine; sodium methylate; sodium hydrogencarbonate; nitrosonium tetrafluoroborate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; toluene; 9.1: Stille coupling;
DOI:10.1021/jm060516e

Reference yield:

: 429682-68-8
N-(4-bromo-1-oxo-2,3-dihydro-1H-inden-5-yl)acetamide

: 851107-82-9
9a-benzyl-6-[4-(methoxymethoxy)phenyl]-3-[(4-methylphenyl)sulfonyl]-8,9,9a,10-tetrahydroindeno[2,1-e]indazol-7(3H)-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: 72 percent / dichlorobis(triphenylphosphine)-palladium(II); triphenylphosphine; lithium chloride / dimethylformamide / 6 h / 100 °C

2.1: 74 percent / NaOMe / ethanol; methanol / 6 h / 20 °C

3.1: 77 percent / H₂ / Pd/C / ethyl acetate; methanol / 1.5 h / 40 °C / atmospheric pressure

4.1: sodium methoxide / methanol / 19 h / 20 °C

5.1: 1.18 g / pyrrolidine; HOAc / tetrahydrofuran / 1.25 h / 100 °C

6.1: 100 percent / NaHCO₃; Br₂ / CH₂Cl₂ / 0.25 h / 0 °C

7.1: 75 percent / sodium methoxide / ethanol; methanol / 6.5 h / 80 °C

8.1: nitrosium tetrafluoroborate / CH₂Cl₂ / 1 h / -35 - 4 °C

8.2: 35 percent / potassium acetate; dibenzo-18-crown-6 / CH₂Cl₂ / 1 h / -35 - 20 °C

9.1: 25 percent / 4-(dimethylamino)-pyridine / CH₂Cl₂ / 2 h / 0 - 20 °C

10.1: 66 percent / tetrakis(triphenylphosphine)-palladium⁽⁰⁾ / toluene / 24 h / 100 °C

With pyrrolidine; dmap; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; bromine; sodium methylate; sodium hydrogencarbonate; nitrosonium tetrafluoroborate; acetic acid; triphenylphosphine; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; 1.1: Stille coupling / 10.1: Stille coupling;
DOI:10.1021/jm060516e