4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline

Base Information

Chemical Name:4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline
CAS No.:75483-04-4
Molecular Formula:C13H12ClNO3
Molecular Weight:265.696
Hs Code.:2933499090
Mol file:75483-04-4.mol

Synonyms:ethyl 1-methyl-4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylate;antioxidant response element inducer-1;4-Chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid ethyl ester;4-chloro-1-methyl-2-oxoquinoline-3-carboxylic acid ethyl ester;3-Quinolinecarboxylic acid,1,2-dihydro-4-chloro-1-methyl-2-oxo-,ethyl ester;ARE inducer-1;1-methyl-2-oxo-4-chloroquinoline-3-carboxylic acid ethyl ester;ethyl 4-chloro-2-oxo-N-methyl-1,2-dihydroquinoline-3-carboxylate;ethyl 4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate;

Suppliers and Price of 4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
Nrf2 Activator II, AI-1
25mg
$ 175.00

Sigma-Aldrich
AI-1 ≥98% (HPLC)
25mg
$ 169.00

Sigma-Aldrich
AI-1 ≥98% (HPLC)
5mg
$ 122.00

Crysdot
Ethyl4-Chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate 95+%
5g
$ 752.00

Chemenu
Ethyl4-Chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate 95%
5g
$ 711.00

American Custom Chemicals Corporation
ETHYL 4-CHLORO-1-METHYL-2-OXO-1,2-DIHYDROQUINOLINE-3-CARBOXYLATE 95.00%
10G
$ 2367.75

American Custom Chemicals Corporation
ETHYL 4-CHLORO-1-METHYL-2-OXO-1,2-DIHYDROQUINOLINE-3-CARBOXYLATE 95.00%
5G
$ 1547.70

American Custom Chemicals Corporation
ETHYL 4-CHLORO-1-METHYL-2-OXO-1,2-DIHYDROQUINOLINE-3-CARBOXYLATE 95.00%
1G
$ 1004.85

AK Scientific
Ethyl4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate
500mg
$ 374.00

Total 2 raw suppliers

Chemical Property of 4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline

Chemical Property:

Vapor Pressure:2.51E-05mmHg at 25°C
Boiling Point:358.7°Cat760mmHg
Flash Point:170.7°C
PSA：48.30000
Density:1.34g/cm³
LogP:2.36860
Storage Temp.:2-8°C
Solubility.:DMSO: ≥15mg/mL

Purity/Quality:: Nrf2 Activator II, AI-1 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 43
Safety Statements: 36/37

MSDS Files:: SDS file from LookChem

Useful:

Description AI-1 (75483-04-4) is a novel antioxidant response element (ARE) activator which activates Nrf2 by covalently modifying Keap1 (Kelch-like ECH-associated protein 1) a negative regulator of Nrf2. Modification of Cys151 of Keap1 by AI-1 disrupts the ability of Keap1 to serve as an adaptor for Cul3-Keap1 ubiquitin ligase complex, thereby stabilizing and inducing transcriptional activation of Nrf2. AI-1 is a useful pharmacological tool for probing the involvement of Nrf2 in cellular physiology.1?Cell permeable.

Technology Process of 4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline

There total 9 articles about 4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 99429-64-8
ethyl ester of 4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylic acid

: 75483-04-4
4-chloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 60 ℃; for 15h;
DOI:10.1007/BF01176973

Reference yield: 90.0%

: 57513-54-9
ethyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate

: 75483-04-4
4-chloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester

Guidance literature:: With trichlorophosphate; for 0.5h; Inert atmosphere; Reflux;
DOI:10.1002/adsc.201300299

Reference yield:

: 10328-92-4
N-Methylisatoic anhydride

: 75483-04-4
4-chloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / NaH / dimethylformamide / 2.5 h / 120 °C

2: 82 percent / POCl₃ / 0.5 h / Heating

With sodium hydride; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570360323