Chemical Property of Sotalol
Chemical Property:
- Appearance/Colour:white crystalline
- Vapor Pressure:1.22E-08mmHg at 25°C
- Melting Point:206.5-207 °C
- Refractive Index:1.57
- Boiling Point:443.3 °C at 760 mmHg
- PKA:pK1 8.2, pK2 9.8(at 25℃)
- Flash Point:221.9 °C
- PSA：86.81000
- Density:1.24 g/cm3
- LogP:2.63420
- Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
- Solubility.:Chloroform (Slightly, Heated), Methanol (Slightly, Sonicated)
- XLogP3:0.2
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:6
- Exact Mass:272.11946368
- Heavy Atom Count:18
- Complexity:330
- Purity/Quality:
-
97% *data from raw suppliers
Sotalol 95+% *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
26-36
- MSDS Files:
-
SDS file from LookChem
Useful:
- Drug Classes:Beta-Adrenergic Receptor Antagonists
- Canonical SMILES:CC(C)NCC(C1=CC=C(C=C1)NS(=O)(=O)C)O
- Recent ClinicalTrials:Prospective Evaluation Analysis and Kinetics Registry
- Recent EU Clinical Trials:First-line cryoablation for early treatment of Persistent Atrial Fibrillation – a randomized study comparing early trigger isolation using the Cryoballoon versus antiarrhythmic medication.
- Recent NIPH Clinical Trials:Clinical study of transplacental anti-arrythmic treatment for fetal tachyarrythmias
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Therapeutic Function
Beta-adrenergic blocker, Antiarrhythmic
-
Clinical Use
The sotalol enantiomers produce different effects onthe heart. Class III action of d-sotalol in the sinus node isassociated with slowing of sinus heart rate, whereas -adrenergicblockade contributes to the decrease in heart rate observedwith 1- or d,1-sotalol. Sotalol is not metabolized, noris it bound significantly to proteins. Elimination occurs byrenal excretion, with more than 80% of the drug eliminatedunchanged. Sotalol is characteristic of class III antiarrhythmicdrugs, in that it prolongs the duration of the action potentialand, thus, increases the effective refractory period of myocardialtissue. It is distinguished from the other class III drugs(amiodarone and bretylium) because of its -adrenergicreceptor–blocking action.
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Drug interactions
Drugs with inherent QT interval–prolonging activity
(i.e., thiazide diuretics and terfenadine) may enhance
the class III effects of sotalol.
