4-methylaminoglutethimide

Base Information

• Chemical Name: 4-methylaminoglutethimide
• CAS No.: 52498-63-2
• Molecular Formula: C₁₄H₁₈N₂O₂
• Molecular Weight: 246.309
• Hs Code.: 2925190090
• Mol file: 52498-63-2.mol

Synonyms:2-(p-Aminophenyl)-2-ethyl-3-methylglutarimide

Chemical Property of 4-methylaminoglutethimide

Chemical Property:

• Vapor Pressure: 1.66E-08mmHg at 25°C
• Boiling Point: 456.1°Cat760mmHg
• Flash Point: 229.7°C
• PSA: 75.68000
• Density: 1.13g/cm³
• LogP: 2.45630

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-methylaminoglutethimide

There total 6 articles about 4-methylaminoglutethimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Ethyl-4-methyl-3-(4-nitrophenyl)piperidin-2,6-dion (52498-62-1) → 3-(4-Aminophenyl)-3-ethyl-4-methylpiperidin-2,6-dion (52498-63-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; Yield given;

DOI:10.1002/ardp.19873200109

Reference yield:

3-Ethyl-4-methyl-3-phenylpiperidin-2,6-dion (107522-34-9) → 3-(4-Aminophenyl)-3-ethyl-4-methylpiperidin-2,6-dion (52498-63-2)

Guidance literature:

Multi-step reaction with 2 steps

1: conc. H₂SO₄, HNO₃ / 2 h / -10 - 0 °C

2: H₂ / 10percent Pd/C / ethanol

With sulfuric acid; hydrogen; nitric acid; palladium on activated charcoal; In ethanol;

DOI:10.1002/ardp.19873200109

Reference yield:

2-phenylbutanenitrile (769-68-6) → 3-(4-Aminophenyl)-3-ethyl-4-methylpiperidin-2,6-dion (52498-63-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 48 percent / Triton B / dioxane; methanol / 15 h / Heating

2: NaOH / aq. ethanol; tetrahydrofuran / 3 h

3: polyphosphoric acid / 3 h / 130 - 140 °C

4: conc. H₂SO₄, HNO₃ / 2 h / -10 - 0 °C

5: H₂ / 10percent Pd/C / ethanol

With sodium hydroxide; PPA; sulfuric acid; hydrogen; nitric acid; N-benzyl-trimethylammonium hydroxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol;

DOI:10.1002/ardp.19873200109

upstream raw materials:

3-Ethyl-4-methyl-3-(4-nitrophenyl)piperidin-2,6-dion

3-Ethyl-4-methyl-3-phenylpiperidin-2,6-dion

2-phenylbutanenitrile

phenylacetonitrile

Refernces