1H-Pyrrole-2-carboxylic acid, 4-cyano-5-ethyl-3-(4-hydroxyphenyl)-1-methyl-, ethyl ester

Base Information

Chemical Name:1H-Pyrrole-2-carboxylic acid, 4-cyano-5-ethyl-3-(4-hydroxyphenyl)-1-methyl-, ethyl ester
CAS No.:851193-72-1
Molecular Formula:C17H18N2O3
Molecular Weight:298.342
Hs Code.:

Synonyms:4-Cyano-5-ethyl-3-(4-hydroxy-phenyl)-1-methyl-1H-pyrrole-2-carboxylic acid ethyl ester;

Suppliers and Price of 1H-Pyrrole-2-carboxylic acid, 4-cyano-5-ethyl-3-(4-hydroxyphenyl)-1-methyl-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
Ethyl4-cyano-5-ethyl-3-(4-hydroxyphenyl)-1-methyl-1H-pyrrole-2-carboxylate 97%
5g
$ 6300.00

Total 1 raw suppliers

Chemical Property of 1H-Pyrrole-2-carboxylic acid, 4-cyano-5-ethyl-3-(4-hydroxyphenyl)-1-methyl-, ethyl ester

Chemical Property:

PSA：75.25000
LogP:3.00848

Purity/Quality:

95%-98% ^*data from raw suppliers

Ethyl4-cyano-5-ethyl-3-(4-hydroxyphenyl)-1-methyl-1H-pyrrole-2-carboxylate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1H-Pyrrole-2-carboxylic acid, 4-cyano-5-ethyl-3-(4-hydroxyphenyl)-1-methyl-, ethyl ester

There total 6 articles about 1H-Pyrrole-2-carboxylic acid, 4-cyano-5-ethyl-3-(4-hydroxyphenyl)-1-methyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 851193-71-0
3-(4-benzyloxy-phenyl)-4-cyano-5-ethyl-1-methyl-1H-pyrrole-2-carboxylic acid ethyl ester

: 851193-72-1
4-cyano-5-ethyl-3-(4-hydroxyphenyl)-1-methyl-1H-pyrrole-2-carboxylic acid ethyl ester

Guidance literature:: With hydrogen; palladium hydroxide on carbon; In tetrahydrofuran; ethanol; at 20 ℃; for 3.5h; under 2585.81 Torr;

Reference yield:

: 851199-54-7
3-(4-benzyloxy-phenyl)-4-cyano-1H-pyrrole-2-carboxylic acid ethyl ester

: 851193-72-1
4-cyano-5-ethyl-3-(4-hydroxyphenyl)-1-methyl-1H-pyrrole-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / dimethyl sulfoxide

2: N-Bromosuccinimide / tetrahydrofuran

3: Hartwig's ligand / tetrahydrofuran / 1 h / 20 °C

4: hydrogen / palladium dihydroxide / tetrahydrofuran; ethanol / 20 °C / 2585.74 Torr

With N-Bromosuccinimide; Hartwig's ligand; hydrogen; potassium carbonate; palladium dihydroxide; In tetrahydrofuran; ethanol; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2006.07.012

Reference yield:

: 851192-88-6
3-(4-benzyloxy-phenyl)-4-cyano-1-methyl-1H-pyrrole-2-carboxylic acid ethyl ester

: 851193-72-1
4-cyano-5-ethyl-3-(4-hydroxyphenyl)-1-methyl-1H-pyrrole-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide / tetrahydrofuran

2: Hartwig's ligand / tetrahydrofuran / 1 h / 20 °C

3: hydrogen / palladium dihydroxide / tetrahydrofuran; ethanol / 20 °C / 2585.74 Torr

With N-Bromosuccinimide; Hartwig's ligand; hydrogen; palladium dihydroxide; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmcl.2006.07.012