1,2,4-Thiadiazole-5-methanol, 3-[4-(trifluoromethyl)phenyl]-

Base Information

Chemical Name:1,2,4-Thiadiazole-5-methanol, 3-[4-(trifluoromethyl)phenyl]-
CAS No.:851224-81-2
Molecular Formula:C10H7F3N2OS
Molecular Weight:260.24
Hs Code.:
DSSTox Substance ID:DTXSID40587860
Wikidata:Q82480343
Mol file:851224-81-2.mol

Synonyms:851224-81-2;1,2,4-THIADIAZOLE-5-METHANOL, 3-[4-(TRIFLUOROMETHYL)PHENYL]-;(3-[4-(Trifluoromethyl)phenyl]-1,2,4-thiadiazol-5-yl)methanol;{3-[4-(Trifluoromethyl)phenyl]-1,2,4-thiadiazol-5-yl}methanol;SCHEMBL4109809;DTXSID40587860;RJSAGKWMYSYKHM-UHFFFAOYSA-N;DB-289845

Suppliers and Price of 1,2,4-Thiadiazole-5-methanol, 3-[4-(trifluoromethyl)phenyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(3-[4-(TRIFLUOROMETHYL)PHENYL]-1,2,4-THIADIAZOL-5-YL)METHANOL 95.00%
5MG
$ 500.81

Total 2 raw suppliers

Chemical Property of 1,2,4-Thiadiazole-5-methanol, 3-[4-(trifluoromethyl)phenyl]-

Chemical Property:

PSA：74.25000
LogP:2.71620
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:260.02311851
Heavy Atom Count:17
Complexity:256

Purity/Quality:

99% ^*data from raw suppliers

(3-[4-(TRIFLUOROMETHYL)PHENYL]-1,2,4-THIADIAZOL-5-YL)METHANOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=NSC(=N2)CO)C(F)(F)F

Technology Process of 1,2,4-Thiadiazole-5-methanol, 3-[4-(trifluoromethyl)phenyl]-

There total 5 articles about 1,2,4-Thiadiazole-5-methanol, 3-[4-(trifluoromethyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 851224-80-1
3-(4-trifluoromethylphenyl)[1,2,4]thiadiazole-5-carboxylic acid ethyl ester

: 851224-81-2
[3-(4-trifluoromethylphenyl)[1,2,4]thiadiazol-5-yl]methanol

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 20 ℃; for 2h;
DOI:10.1021/jm070511x

Reference yield: 85.0%

: C₁₂H₁₀F₃NO₂S₂

: 851224-81-2
[3-(4-trifluoromethylphenyl)[1,2,4]thiadiazol-5-yl]methanol

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; ethanol; at 40 ℃;
DOI:10.1021/op700141u

Reference yield:

: 851224-79-8
5-(4-trifluoromethylphenyl)[1,3,4]oxathiazol-2-one

: 851224-81-2
[3-(4-trifluoromethylphenyl)[1,2,4]thiadiazol-5-yl]methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / 1,2-dichloro-benzene / 20 h / 160 °C

2: 97 percent / NaBH₄ / ethanol / 2 h / 20 °C

With sodium tetrahydroborate; In ethanol; 1,2-dichloro-benzene;
DOI:10.1021/jm070511x