Technology Process of Oxazole, 4-[[[(3R)-3-azidodecyl]oxy]methyl]-4,5-dihydro-2-phenyl-, (4R)-
There total 7 articles about Oxazole, 4-[[[(3R)-3-azidodecyl]oxy]methyl]-4,5-dihydro-2-phenyl-, (4R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / -20 - 0 °C
2.1: potassium carbonate / tetrahydrofuran; methanol / 4 h / 20 °C
3.1: dmap; triethylamine / dichloromethane / 0 - 20 °C
4.1: sodium azide / N,N-dimethyl-formamide / 140 °C
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C
6.1: dmap; triethylamine / dichloromethane / 0 - 20 °C
7.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 °C
7.2: 48 h / 0 °C
With
dmap; sodium azide; potassium tert-butylate; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C
2.1: dmap; triethylamine / dichloromethane / 0 - 20 °C
3.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 °C
3.2: 48 h / 0 °C
With
dmap; potassium tert-butylate; tetrabutyl ammonium fluoride; triethylamine;
In
tetrahydrofuran; dichloromethane;
