3-Pyridinecarboxamide, 4-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-[(2 ,3-dichlorophenyl)methyl]-5,5-difluoro-1,2,5,6-tetrahydro-

Base Information

Chemical Name:3-Pyridinecarboxamide, 4-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-[(2 ,3-dichlorophenyl)methyl]-5,5-difluoro-1,2,5,6-tetrahydro-
CAS No.:851314-26-6
Molecular Formula:C31H27Cl3F4N2O2
Molecular Weight:641.92
Hs Code.:

3-Pyridinecarboxamide,
4-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-[(2
,3-dichlorophenyl)methyl]-5,5-difluoro-1,2,5,6-tetrahydro-

Synonyms:

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Chemical Property of 3-Pyridinecarboxamide, 4-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-[(2 ,3-dichlorophenyl)methyl]-5,5-difluoro-1,2,5,6-tetrahydro-

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Technology Process of 3-Pyridinecarboxamide, 4-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-[(2 ,3-dichlorophenyl)methyl]-5,5-difluoro-1,2,5,6-tetrahydro-

There total 10 articles about 3-Pyridinecarboxamide, 4-[4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl]-N-cyclopropyl-N-[(2 ,3-dichlorophenyl)methyl]-5,5-difluoro-1,2,5,6-tetrahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 851314-31-3
C₃₆H₃₅Cl₃F₄N₂O₄

: 851314-26-6
4-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-5,5-difluoro-1,2,5,6-tetrahydropyridine-3-carboxylic acid cyclopropyl-(2,3-dichlorobenzyl)amide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 0 - 20 ℃; for 1.5h;

Reference yield:

: 851314-44-8
1-benzyl-4-{4-[3-(tert-butyldimethylsilanyloxy)propyl]phenyl}-5,5-difluoro-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid ethyl ester

: 851314-26-6
4-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-5,5-difluoro-1,2,5,6-tetrahydropyridine-3-carboxylic acid cyclopropyl-(2,3-dichlorobenzyl)amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium on activated charcoal; hydrogen; acetic acid / ethanol / 4 h / 20 °C

2.1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / toluene / 2 h / Reflux

3.1: water; sodium hydroxide / ethanol / 5 h

3.2: 72 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 2 h / 0 - 20 °C

With hydrogenchloride; tributylphosphine; palladium on activated charcoal; water; hydrogen; acetic acid; sodium hydroxide; 1,1'-azodicarbonyl-dipiperidine; In 1,4-dioxane; ethanol; dichloromethane; toluene; 2.1: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2009.09.104

Reference yield:

: 851314-50-6
4-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-5,5-difluoro-5,6-dihydro-2H-pyridine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester

: 851314-26-6
4-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-5,5-difluoro-1,2,5,6-tetrahydropyridine-3-carboxylic acid cyclopropyl-(2,3-dichlorobenzyl)amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; sodium hydroxide / ethanol / 5 h

1.2: 72 h / 20 °C

2.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 2 h / 0 - 20 °C

With hydrogenchloride; water; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2009.09.104