7H-Pyrrolo[2,3-d]pyrimidine-7-carboxamide, 4-chloro-N-[2-methyl-5-[[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl )benzoyl]amino]phenyl]-

Base Information

Chemical Name:7H-Pyrrolo[2,3-d]pyrimidine-7-carboxamide, 4-chloro-N-[2-methyl-5-[[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl )benzoyl]amino]phenyl]-
CAS No.:851319-33-0
Molecular Formula:C26H19ClF3N7O2
Molecular Weight:553.931
Hs Code.:

7H-Pyrrolo[2,3-d]pyrimidine-7-carboxamide,
4-chloro-N-[2-methyl-5-[[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl
)benzoyl]amino]phenyl]-

Synonyms:

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Chemical Property of 7H-Pyrrolo[2,3-d]pyrimidine-7-carboxamide, 4-chloro-N-[2-methyl-5-[[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl )benzoyl]amino]phenyl]-

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Technology Process of 7H-Pyrrolo[2,3-d]pyrimidine-7-carboxamide, 4-chloro-N-[2-methyl-5-[[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl )benzoyl]amino]phenyl]-

There total 4 articles about 7H-Pyrrolo[2,3-d]pyrimidine-7-carboxamide, 4-chloro-N-[2-methyl-5-[[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl )benzoyl]amino]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₁₈ClF₃N₇O₂Pol

: 851319-33-0
4-chloro-pyrrolo[2,3-d]pyrimidine-7-carboxylic acid {2-methyl-5-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-benzoylamino]-phenyl}-amide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; water; for 0.5h; PAL-resin

Reference yield:

: 32315-10-9
bis(trichloromethyl) carbonate

: 851319-35-2
N-(3-amino-4-methylphenyl)-3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzamide

: 3680-69-1
4-chloro-1H-pyrrolo[2,3-d]pyrimidine

: 851319-33-0
4-chloro-pyrrolo[2,3-d]pyrimidine-7-carboxylic acid {2-methyl-5-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-benzoylamino]-phenyl}-amide

Guidance literature:: bis(trichloromethyl) carbonate; 4-chloro-1H-pyrrolo[2,3-d]pyrimidine; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 ℃; for 3h;

N-(3-amino-4-methylphenyl)-3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzamide; In tetrahydrofuran; at 20 ℃; for 18h; Product distribution / selectivity;

Reference yield:

: 119-32-4
4-Methyl-3-nitroanilin

: 851319-33-0
4-chloro-pyrrolo[2,3-d]pyrimidine-7-carboxylic acid {2-methyl-5-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-benzoylamino]-phenyl}-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 24 h

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 0 °C

3.2: 18 h / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;