Chemical Property of 7-(7-Amino-5-azaspiro[2.4]heptan-5-yl)-8-chloro-6-fluoro-1-(2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid--water (2/3)
Chemical Property:
- Vapor Pressure:1.06E-16mmHg at 25°C
- Melting Point:145-147°C (dec.)
- Boiling Point:629.2oC at 760mmHg
- Flash Point:334.3oC
- PSA：97.79000
- LogP:3.40360
- Storage Temp.:Hygroscopic, -20°C Freezer, Under Inert Atmosphere
- Solubility.:Aqueous Base (Slightly), DMSO (Slightly), Methanol (Very Slightly, Heated)
- Hydrogen Bond Donor Count:7
- Hydrogen Bond Acceptor Count:19
- Rotatable Bond Count:6
- Exact Mass:872.2326450
- Heavy Atom Count:59
- Complexity:761
- Purity/Quality:
-
99% *data from raw suppliers
Sitafloxacin Sesquihydrate *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C1CC12CN(CC2N)C3=C(C=C4C(=C3Cl)N(C=C(C4=O)C(=O)O)C5CC5F)F.C1CC12CN(CC2N)C3=C(C=C4C(=C3Cl)N(C=C(C4=O)C(=O)O)C5CC5F)F.O.O.O
- Isomeric SMILES:C1CC12CN(C[C@H]2N)C3=C(C=C4C(=C3Cl)N(C=C(C4=O)C(=O)O)C5C[C@@H]5F)F.C1CC12CN(C[C@H]2N)C3=C(C=C4C(=C3Cl)N(C=C(C4=O)C(=O)O)C5C[C@@H]5F)F.O.O.O
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Description
The fluoroquinolone antibacterial agent sitafloxacin hydrate
was developed by Daiichi Sankyo and was approved
and launched last year in Japan. Sitafloxacin’s mode of action
is through inhibition of DNA gyrase and topoisomerase
IV. It is indicated for the treatment of inflammatory infections
such as laryngopharyngitis, adenoiditis, acute bronchitis,
pneumonia, secondary infections due to chronic respiratory
lesions, cystitis, pyelonephritis, urethritis, cervicitis,
otitismedia, sinusitis, periodontitis, and pericoronitis and jaw
inflammation. Due to its broad spectrum of potent antibacterial
activity, sitafloxacin is expected to be clinically effective
in treating severe cases of bacterial infection, relapse/recrudescence of infection and infections in which resistant
bacteria are suspected to be the cause.
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Uses
Sitafloxacin is a new-generation, broad-spectrum oral fluoroquinolone antibiotic.
It is very active against many Gram-positive, Gram-negative and anaerobic clinical isolates, including strains resistant to other fluoroquinolones, was recently approved in Antibacterial
