2,3,5,6,7,8-Hexahydroxy-1,4-naphthalenedione

Base Information

• Chemical Name: 2,3,5,6,7,8-Hexahydroxy-1,4-naphthalenedione
• CAS No.: 476-37-9
• Molecular Formula: C10H6O8
• Molecular Weight: 254.153
• Mol file: 476-37-9.mol

Synonyms:Hexahydroxy-1,4-naphthalenedione;2.3.5.6.7.8-Hexahydroxy-naphtho-1.4-chinon;Hexahydroxy-2,3-naphthalenedione;Hexahydroxynaphthalene-1,4-dione;2.3.6.7-Tetrahydroxy-naphthazarin;Hexahydroxynaphthalene-2,3-dione;2,3,5,6,7,8-hexahydroxy-naphthoquinone;spinochrome E;2,3,5,6,7,8-hexahydroxy-1,4-naphthoquinone;

Chemical Property of 2,3,5,6,7,8-Hexahydroxy-1,4-naphthalenedione

Chemical Property:

• PSA: 155.52000
• LogP: -2.00680

Purity/Quality:

99% ,98%,Electron Grade , ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3,5,6,7,8-Hexahydroxy-1,4-naphthalenedione

There total 5 articles about 2,3,5,6,7,8-Hexahydroxy-1,4-naphthalenedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

3-amino-2,5,8-trihydroxy-6,7-diethoxy-1,4-naphthoquinone (1379509-87-1) → 2,3,5,6,7,8-hexahydroxynaphthalene-1,4-dione, (476-37-9)

Guidance literature:

3-amino-2,5,8-trihydroxy-6,7-diethoxy-1,4-naphthoquinone; With aluminum (III) chloride; In nitrobenzene; at 70 ℃; for 6h;

With hydrogenchloride; water; for 0.166667h; Reflux;

DOI:10.1007/s10600-012-0204-6

Reference yield:

2,3-dichloro-6,7-diethoxy-5,8-dihydroxy-1,4-naphthoquinone → 2,3,5,6,7,8-hexahydroxynaphthalene-1,4-dione, (476-37-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: water; sodium nitrite / ethanol / 1 h / Reflux

1.2: pH Ca_. 6

2.1: sodium dithionite; water / 0.5 h

3.1: aluminum (III) chloride / nitrobenzene / 6 h / 70 °C

3.2: 0.17 h / Reflux

With aluminum (III) chloride; sodium dithionite; water; sodium nitrite; In ethanol; nitrobenzene;

DOI:10.1007/s10600-012-0204-6

Reference yield:

2.3-Dihydroxy-5.6.7.8-tetramethoxy-naphtho-1.4-chinon (5060-98-0) → 2,3,5,6,7,8-hexahydroxynaphthalene-1,4-dione, (476-37-9)

Guidance literature:

With hydrogen bromide; Heating;

DOI:10.1039/j39660000426

upstream raw materials:

2.3-Dihydroxy-5.6.7.8-tetramethoxy-naphtho-1.4-chinon

3,4,5,6-Tetramethoxy-phthalaldehyd

1,2-bis-chloromethyl-3,4,5,6-tetramethoxy-benzene

3-amino-2,5,8-trihydroxy-6,7-diethoxy-1,4-naphthoquinone

Downstream raw materials:

Cumene hydroperoxide