2-amino-5-methoxy-2,3-dihydro-1H-inden-1-one

Base Information

Chemical Name:2-amino-5-methoxy-2,3-dihydro-1H-inden-1-one
CAS No.:6285-85-4
Molecular Formula:C₁₀H₁₁NO₂*ClH
Molecular Weight:213.664
Hs Code.:

Synonyms:1-Indanone,2-amino-5-methoxy-, hydrochloride (8CI); 1H-Inden-1-one, 2-amino-2,3-dihydro-5-methoxy-,hydrochloride (9CI); NSC 10680

Suppliers and Price of 2-amino-5-methoxy-2,3-dihydro-1H-inden-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 5 raw suppliers

Chemical Property of 2-amino-5-methoxy-2,3-dihydro-1H-inden-1-one

Chemical Property:

Vapor Pressure:7.28E-05mmHg at 25°C
Boiling Point:342.9°Cat760mmHg
Flash Point:187.7°C
Density:1.208g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-amino-5-methoxy-2,3-dihydro-1H-inden-1-one

There total 2 articles about 2-amino-5-methoxy-2,3-dihydro-1H-inden-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 7235-36-1
5-methoxy-indan-1,2-dione 2-oxime

: 6285-85-4
5-methoxy-2-amino-1-indanone hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; water; for 2h;

Reference yield:

: 5111-70-6
5-methoxy-1-indanone

: 6285-85-4
5-methoxy-2-amino-1-indanone hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) HCl, 2.) isoamyl nitrite / 1.) ether, 2.) ether,

2: 65 percent / 12 M HCl, H₂ / 5percent Pd/C / H₂O; methanol / 2 h

With hydrogenchloride; hydrogen; isopentyl nitrite; palladium on activated charcoal; In methanol; water;

Reference yield:

: 6285-85-4
5-methoxy-2-amino-1-indanone hydrochloride

: (2'S,3''R)-tert-butyl 1''-benzyl-5'-methoxy-1',2''-dioxo-2-thioxo-1',3'-dihydrodispiro-[indene-2',4-imidazolidine-5,3''-indoline]-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / dichloromethane; water / 0.25 h / 0 °C

1.2: 1.5 h / 0 °C

2.1: C₃₂H₂₈F₆N₄O₃ / 1,2-dichloro-ethane / 0.08 h / 20 °C

2.2: 20 °C

With C₃₂H₂₈F₆N₄O₃; sodium hydrogencarbonate; In dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1021/acs.orglett.8b01389