2-Propenamide, 3-(4-hydroxy-3,5-dimethoxyphenyl)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-

Base Information

Chemical Name:2-Propenamide, 3-(4-hydroxy-3,5-dimethoxyphenyl)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-
CAS No.:86436-49-9
Molecular Formula:C31H33NO9
Molecular Weight:563.595
Hs Code.:
ChEMBL ID:CHEMBL282519

Synonyms:N-Inapinoyl-N-deacetylcolchicine;86436-49-9;2-Propenamide, 3-(4-hydroxy-3,5-dimethoxyphenyl)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-;2-Propenamide, 3-(4-hydroxy-3,5-dimethoxyphenyl)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)-;CHEMBL282519;(E)-3-(4-hydroxy-3,5-dimethoxy-phenyl)-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]prop-2-enamide

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Propenamide, 3-(4-hydroxy-3,5-dimethoxyphenyl)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-

Chemical Property:

Vapor Pressure:8.35E-32mmHg at 25°C
Boiling Point:869.2°Cat760mmHg
Flash Point:479.5°C
Density:1.32g/cm³
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:9
Exact Mass:563.21553163
Heavy Atom Count:41
Complexity:1050

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C2C(=CC1=O)C(CCC3=CC(=C(C(=C32)OC)OC)OC)NC(=O)C=CC4=CC(=C(C(=C4)OC)O)OC
Isomeric SMILES:COC1=CC=C2C(=CC1=O)[C@H](CCC3=CC(=C(C(=C32)OC)OC)OC)NC(=O)/C=C/C4=CC(=C(C(=C4)OC)O)OC

Technology Process of 2-Propenamide, 3-(4-hydroxy-3,5-dimethoxyphenyl)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-

There total 3 articles about 2-Propenamide, 3-(4-hydroxy-3,5-dimethoxyphenyl)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 86436-48-8
acetate of N-sinapinoyldeacetylcolchicine

: 86436-49-9
N-sinapinoyldeacetylcolchicine

Guidance literature:: With ammonium hydroxide; In acetone; for 2h; Ambient temperature;
DOI:10.1021/jm00364a006

Reference yield:

: 3476-50-4
deacetylcolchicine

: 86436-49-9
N-sinapinoyldeacetylcolchicine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / benzene / 8 h / 55 - 60 °C

2: 94 percent / concd. ammonia / acetone / 2 h / Ambient temperature

With pyridine; ammonium hydroxide; In acetone; benzene;
DOI:10.1021/jm00364a006

Reference yield:

: 39657-48-2
3-(4-acetoxy-3,5-dimethoxyphenyl)prop-2-enoyl chloride

: 86436-49-9
N-sinapinoyldeacetylcolchicine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / benzene / 8 h / 55 - 60 °C

2: 94 percent / concd. ammonia / acetone / 2 h / Ambient temperature

With pyridine; ammonium hydroxide; In acetone; benzene;
DOI:10.1021/jm00364a006