Technology Process of 2-Cyclohexene-1-acetaldehyde,
4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-ethenyl-, (1S,4S)-
There total 17 articles about 2-Cyclohexene-1-acetaldehyde,
4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-ethenyl-, (1S,4S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Dess-Martin periodane;
In
dichloromethane;
at 20 ℃;
for 7h;
DOI:10.1055/s-2005-862388
- Guidance literature:
-
Multi-step reaction with 15 steps
1.1: 84 percent / Hg(OAc)2 / 18 h / 50 °C
2.1: 88 percent / i-Bu3Al / CH2Cl2 / 1 h / 20 °C
3.1: imidazole; 4-DMAP / CH2Cl2 / 0.25 h / 20 °C
4.1: TMSCl; EtOH / 0.33 h / 20 °C
5.1: 95 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / 0.5 h / 20 °C
6.1: 95 percent / benzene / 1.5 h / 80 °C
7.1: 95 percent / i-Bu2AlH / tetrahydrofuran / 0.17 h / 20 °C
8.1: (+)-DIPT; (i-PrO)4Ti; TBHP / 4 Angstroem molecular sieves / CH2Cl2 / 10 h / -25 °C
9.1: I2; Ph3P; imidazole / benzene / 0.33 h / 20 °C
10.1: Zn; HOAc / 2 h / 50 °C
11.1: Cl2Ru=CHPh(PCy3)2 / CH2Cl2 / 48 h / 20 °C
11.2: hydrolysis
12.1: 91 percent / imidazole; 4-DMAP / CH2Cl2 / 0.67 h / 20 °C
13.1: 71 percent / n-Bu4NF; HOAc / tetrahydrofuran / 6 h / 20 °C
14.1: 90 percent / Dess-Martin periodinane / CH2Cl2 / 7 h / 20 °C
With
1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; chloro-trimethyl-silane; oxalyl dichloride; ethanol; L-(+)-diisopropyl tartrate; mercury(II) diacetate; tetrabutyl ammonium fluoride; iodine; triisobutylaluminum; diisobutylaluminium hydride; Dess-Martin periodane; acetic acid; dimethyl sulfoxide; triethylamine; triphenylphosphine; zinc;
Grubbs catalyst first generation; 4 A molecular sieve;
In
tetrahydrofuran; dichloromethane; benzene;
2.1: reductive Claisen rearrangement / 5.1: Swern oxidation / 6.1: Wittig reaction / 8.1: Katsuki-Sharpless asymmetric epoxidation / 15.1: Dess-Martin oxidation;
DOI:10.1055/s-2005-862388
- Guidance literature:
-
Multi-step reaction with 13 steps
1.1: imidazole; 4-DMAP / CH2Cl2 / 0.25 h / 20 °C
2.1: TMSCl; EtOH / 0.33 h / 20 °C
3.1: 95 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / 0.5 h / 20 °C
4.1: 95 percent / benzene / 1.5 h / 80 °C
5.1: 95 percent / i-Bu2AlH / tetrahydrofuran / 0.17 h / 20 °C
6.1: (+)-DIPT; (i-PrO)4Ti; TBHP / 4 Angstroem molecular sieves / CH2Cl2 / 10 h / -25 °C
7.1: I2; Ph3P; imidazole / benzene / 0.33 h / 20 °C
8.1: Zn; HOAc / 2 h / 50 °C
9.1: Cl2Ru=CHPh(PCy3)2 / CH2Cl2 / 48 h / 20 °C
9.2: hydrolysis
10.1: 91 percent / imidazole; 4-DMAP / CH2Cl2 / 0.67 h / 20 °C
11.1: 71 percent / n-Bu4NF; HOAc / tetrahydrofuran / 6 h / 20 °C
12.1: 90 percent / Dess-Martin periodinane / CH2Cl2 / 7 h / 20 °C
With
1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; chloro-trimethyl-silane; oxalyl dichloride; ethanol; L-(+)-diisopropyl tartrate; tetrabutyl ammonium fluoride; iodine; diisobutylaluminium hydride; Dess-Martin periodane; acetic acid; dimethyl sulfoxide; triethylamine; triphenylphosphine; zinc;
Grubbs catalyst first generation; 4 A molecular sieve;
In
tetrahydrofuran; dichloromethane; benzene;
3.1: Swern oxidation / 4.1: Wittig reaction / 6.1: Katsuki-Sharpless asymmetric epoxidation / 13.1: Dess-Martin oxidation;
DOI:10.1055/s-2005-862388
![2-[(1S,4S)-4-(tert-Butyl-dimethyl-silanyloxy)-1-vinyl-cyclohex-2-enyl]-ethanol](/Databaselist/images/loading.webp)
