9-amino-6-trifluoromethylbenzonorbornene

Base Information

• Chemical Name: 9-amino-6-trifluoromethylbenzonorbornene
• CAS No.: 87405-61-6
• Molecular Formula: C₁₂H₁₂F₃N
• Molecular Weight: 227.229
• Mol file: 87405-61-6.mol

Synonyms:9-Amino-6-trifluoromethylbenzonorbornene;1,4-Methanonaphthalen-9-amine,1,2,3,4-tetrahydro-6-(trifluoromethyl);anti-9-amino-6-(trifluoromethyl)benzonorbornene;

Chemical Property of 9-amino-6-trifluoromethylbenzonorbornene

Chemical Property:

• Vapor Pressure: 0.0116mmHg at 25°C
• Boiling Point: 261.4°Cat760mmHg
• Flash Point: 114°C
• PSA: 26.02000
• Density: 1.29g/cm³
• LogP: 3.70760

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9-amino-6-trifluoromethylbenzonorbornene

There total 2 articles about 9-amino-6-trifluoromethylbenzonorbornene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(1R,4S,9R)-9-Azido-6-trifluoromethyl-1,2,3,4-tetrahydro-1,4-methano-naphthalene → anti-9-amino-6-(trifluoromethyl)benzonorbornene (87405-61-6,90131-00-3,90131-01-4)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 12h; Ambient temperature;

DOI:10.1021/jm00395a005

Reference yield:

6-(Trifluoromethyl)benzonorbornadiene (85977-25-9) → anti-9-amino-6-(trifluoromethyl)benzonorbornene (87405-61-6,90131-00-3,90131-01-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 33 percent / (diacetoxyiodo)benzene, azidotrimethylsilane / CH₂Cl₂ / 5 h / -25 °C

2: 91 percent / LiAlH₄ / diethyl ether / 12 h / Ambient temperature

With lithium aluminium tetrahydride; [bis(acetoxy)iodo]benzene; trimethylsilylazide; In diethyl ether; dichloromethane;

DOI:10.1021/jm00395a005

upstream raw materials:

6-(Trifluoromethyl)benzonorbornadiene

Refernces